Mumps: Interdisciplinary Review for Pharmacy, Nursing & Medical Secretary
Abstract
Background: Mumps is a highly communicable rubulavirus infection with declining incidence after MMR but continuing outbreaks, especially in congregate settings.
Aim: To synthesize interdisciplinary, practice-oriented guidance for pharmacists, nurses, and medical secretaries on prevention, evaluation, and management.
Methods: Narrative review of virology and pathophysiology, post-vaccine epidemiology, clinical features, differential diagnosis, laboratory confirmation, patient education, and team-based operational workflows.
Results: Mumps presents after a prodrome with parotitis in over 70% of cases; transmission occurs from two days before to five days after onset. RT-PCR on buccal swabs within three days maximizes yield; IgM may be delayed or absent after vaccination. Supportive care is standard; five-day isolation and droplet precautions limit spread. Orchitis, aseptic meningitis, and multisystem complications persist but are less frequent in vaccinated cohorts. Team actions—rapid triage and high-quality specimens (nursing), optimized analgesia and closure of vaccine gaps including outbreak third doses (pharmacy), and precise documentation, reporting, and communication with schools, employers, and public health (medical secretaries)—accelerate control and reduce morbidity.
Conclusion: Coordinated, role-explicit workflows anchored in vaccination, timely diagnosis, and standardized communication are essential to prevent and contain mumps outbreaks and sustain public-health gains.
Full text article
References
Lam E, Rosen JB, Zucker JR. Mumps: an Update on Outbreaks, Vaccine Efficacy, and Genomic Diversity. Clin Microbiol Rev. 2020 Mar 18;33(2)
Almansour I. Mumps Vaccines: Current Challenges and Future Prospects. Front Microbiol. 2020;11:1999.
Su SB, Chang HL, Chen AK. Current Status of Mumps Virus Infection: Epidemiology, Pathogenesis, and Vaccine. Int J Environ Res Public Health. 2020 Mar 05;17(5)
Wu H, Wang F, Tang D, Han D. Mumps Orchitis: Clinical Aspects and Mechanisms. Front Immunol. 2021;12:582946.
Marin M, Marlow M, Moore KL, Patel M. Recommendation of the Advisory Committee on Immunization Practices for Use of a Third Dose of Mumps Virus-Containing Vaccine in Persons at Increased Risk for Mumps During an Outbreak. MMWR Morb Mortal Wkly Rep. 2018 Jan 12;67(1):33-38.
Hviid A, Rubin S, Mühlemann K. Mumps. Lancet. 2008 Mar 15;371(9616):932-44.
Shepersky L, Marin M, Zhang J, Pham H, Marlow MA. Mumps in Vaccinated Children and Adolescents: 2007-2019. Pediatrics. 2021 Dec 01;148(6)
Shah M, Quinlisk P, Weigel A, Riley J, James L, Patterson J, Hickman C, Rota PA, Stewart R, Clemmons N, Kalas N, Cardemil C., Iowa Mumps Outbreak Response Team. Mumps Outbreak in a Highly Vaccinated University-Affiliated Setting Before and After a Measles-Mumps-Rubella Vaccination Campaign-Iowa, July 2015-May 2016. Clin Infect Dis. 2018 Jan 06;66(1):81-88.
RUSSELL RR, DONALD JC. The neurological complications of mumps. Br Med J. 1958 Jul 05;2(5087):27-30.
Dayan GH, Quinlisk MP, Parker AA, Barskey AE, Harris ML, Schwartz JM, Hunt K, Finley CG, Leschinsky DP, O'Keefe AL, Clayton J, Kightlinger LK, Dietle EG, Berg J, Kenyon CL, Goldstein ST, Stokley SK, Redd SB, Rota PA, Rota J, Bi D, Roush SW, Bridges CB, Santibanez TA, Parashar U, Bellini WJ, Seward JF. Recent resurgence of mumps in the United States. N Engl J Med. 2008 Apr 10;358(15):1580-9.
Siegel M, Fuerst HT, Peress NS. Comparative fetal mortality in maternal virus diseases. A prospective study on rubella, measles, mumps, chicken pox and hepatitis. N Engl J Med. 1966 Apr 07;274(14):768-71.
Enders M, Rist B, Enders G. [Frequency of spontaneous abortion and premature birth after acute mumps infection in pregnancy]. Gynakol Geburtshilfliche Rundsch. 2005 Jan;45(1):39-43.
McNabb SJ, Jajosky RA, Hall-Baker PA, Adams DA, Sharp P, Anderson WJ, Javier AJ, Jones GJ, Nitschke DA, Worshams CA, Richard RA., Centers for Disease Control and Prevention (CDC). Summary of notifiable diseases --- United States, 2005. MMWR Morb Mortal Wkly Rep. 2007 Mar 30;54(53):1-92.
Centers for Disease Control and Prevention (CDC). Updated recommendations for isolation of persons with mumps. MMWR Morb Mortal Wkly Rep. 2008 Oct 10;57(40):1103-5.
Brook I. Diagnosis and management of parotitis. Arch Otolaryngol Head Neck Surg. 1992 May;118(5):469-71.
Wright WF, Pinto CN, Palisoc K, Baghli S. Viral (aseptic) meningitis: A review. J Neurol Sci. 2019 Mar 15;398:176-183.
Trojian TH, Lishnak TS, Heiman D. Epididymitis and orchitis: an overview. Am Fam Physician. 2009 Apr 01;79(7):583-7.
the Association for the Study of Infectious Disease. A retrospective survey of the complications of mumps. J R Coll Gen Pract. 1974 Aug;24(145):552-6.
Gray JA. Mumps. Br Med J. 1973 Feb 10;1(5849):338-40.
Barskey AE, Schulte C, Rosen JB, Handschur EF, Rausch-Phung E, Doll MK, Cummings KP, Alleyne EO, High P, Lawler J, Apostolou A, Blog D, Zimmerman CM, Montana B, Harpaz R, Hickman CJ, Rota PA, Rota JS, Bellini WJ, Gallagher KM. Mumps outbreak in Orthodox Jewish communities in the United States. N Engl J Med. 2012 Nov 01;367(18):1704-13.
Zamir CS, Schroeder H, Shoob H, Abramson N, Zentner G. Characteristics of a large mumps outbreak: Clinical severity, complications and association with vaccination status of mumps outbreak cases. Hum Vaccin Immunother. 2015;11(6):1413-7.
Di Pietrantonj C, Rivetti A, Marchione P, Debalini MG, Demicheli V. Vaccines for measles, mumps, rubella, and varicella in children. Cochrane Database Syst Rev. 2021 Nov 22;11(11):CD004407.
McLean HQ, Fiebelkorn AP, Temte JL, Wallace GS., Centers for Disease Control and Prevention. Prevention of measles, rubella, congenital rubella syndrome, and mumps, 2013: summary recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2013 Jun 14;62(RR-04):1-34.
Ogbuanu IU, Kutty PK, Hudson JM, Blog D, Abedi GR, Goodell S, Lawler J, McLean HQ, Pollock L, Rausch-Phung E, Schulte C, Valure B, Armstrong GL, Gallagher K. Impact of a third dose of measles-mumps-rubella vaccine on a mumps outbreak. Pediatrics. 2012 Dec;130(6):e1567-74.
Nelson GE, Aguon A, Valencia E, Oliva R, Guerrero ML, Reyes R, Lizama A, Diras D, Mathew A, Camacho EJ, Monforte MN, Chen TH, Mahamud A, Kutty PK, Hickman C, Bellini WJ, Seward JF, Gallagher K, Fiebelkorn AP. Epidemiology of a mumps outbreak in a highly vaccinated island population and use of a third dose of measles-mumps-rubella vaccine for outbreak control--Guam 2009 to 2010. Pediatr Infect Dis J. 2013 Apr;32(4):374-80.
Cardemil CV, Dahl RM, James L, Wannemuehler K, Gary HE, Shah M, Marin M, Riley J, Feikin DR, Patel M, Quinlisk P. Effectiveness of a Third Dose of MMR Vaccine for Mumps Outbreak Control. N Engl J Med. 2017 Sep 07;377(10):947-956
Abedi GR, Mutuc JD, Lawler J, Leroy ZC, Hudson JM, Blog DS, Schulte CR, Rausch-Phung E, Ogbuanu IU, Gallagher K, Kutty PK. Adverse events following a third dose of measles, mumps, and rubella vaccine in a mumps outbreak. Vaccine. 2012 Nov 19;30(49):7052-8.
Seither R, Yusuf OB, Dramann D, Calhoun K, Mugerwa-Kasujja A, Knighton CL. Coverage with Selected Vaccines and Exemption from School Vaccine Requirements Among Children in Kindergarten - United States, 2022-23 School Year. MMWR Morb Mortal Wkly Rep. 2023 Nov 10;72(45):1217-1224.
Barbel P, Peterson K, Heavey E. Mumps makes a comeback: What nurses need to know. Nursing. 2017 Jan;47(1):15-17.
Davison P, Rausch-Phung EA, Morris J. Mumps. InStatPearls [Internet] 2024 May 1. StatPearls Publishing.
Authors
Copyright (c) 2024 Ahmed Abdullah Abualgasim Alamir, Fehaid Oqalaa Radhi Alanazi, Abeer Abdullah Al-Alawi, Ali Ahmed Mohammed Matari, Salman Abdullah Alghamdi, Aljohirha Mohammed Alotibia, Haya Nada Alnoumesy, Eman Shayah Jehad Alenazi, Amani Zaben Mashan Alanazi, Fayza Karman Nasha Al Hazmi

This work is licensed under a Creative Commons Attribution 4.0 International License.