Issue
Date Log
Copyright (c) 2026 Faisal Abdullah Shaher Alqahtani, Seham Abdu Ali Khafy, Saad Abdulrahman Saad Alsahli, Hashel Ali Saleh Al Abdullah, Malak Yahya Ali Jraibi, Abdullah Ali Alawadh, Rashed Abdullah Almuhaini, Maryam Saleh Al-Hafizi, Faiz Ali Ahmed Kaabi, Maryam Hejji Bumozah

This work is licensed under a Creative Commons Attribution 4.0 International License.
From Biological Specimen to Clinical Decision: Integrating Forensic Toxicology, Emergency Medical Services, Nursing Documentation, Radiological Findings, Nutritional Confounders, and Social Context
Corresponding Author(s) : Faisal Abdullah Shaher Alqahtani
Saudi Journal of Medicine and Public Health, Vol. 3 No. 1 (2026)
Abstract
Background: Toxicological results seldom reach clinical decisions as isolated facts; they emerge from a chain of prehospital, nursing, laboratory, imaging, and social processes. Aim: To synthesize evidence on how forensic toxicology, emergency medical services (EMS), nursing documentation, radiology, nutritional status, and social context jointly shape the interpretation of biological specimens. Methods: A narrative review of peer-reviewed literature and surveillance reports published between 2017 and 2024 was conducted, with thematic synthesis across six domains. Results: Interpretive error accumulates at handoffs. Specimen timing and matrix, incomplete prehospital and nursing records, uninformative imaging requisitions, unrecognized nutritional modifiers, and stigma-related or structural biases each alter inference. Analytical advances such as high-resolution mass spectrometry expand detection but increase interpretive demands. Conclusion: An integrated, documentation-anchored framework linking specimen provenance to contextual metadata may reduce misinterpretation and support more accurate and equitable decisions.
Keywords
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX
- 1. Akhu‐Zaheya, L., Al‐Maaitah, R., & Bany Hani, S. (2018). Quality of nursing documentation: Paper‐based health records versus electronic‐based health records. Journal of clinical nursing, 27(3-4), e578-e589.
- 2. Anderson, L. J., Flynn, A., & Pilgrim, J. L. (2017). A global epidemiological perspective on the toxicology of drug-facilitated sexual assault: A systematic review. Journal of forensic and legal medicine, 47, 46-54.
- 3. Blanco, C., Wiley, T. R., Lloyd, J. J., Lopez, M. F., & Volkow, N. D. (2020). America’s opioid crisis: the need for an integrated public health approach. Translational psychiatry, 10(1), 167.
- 4. Brockbals, L., Staeheli, S. N., Gascho, D., Ebert, L. C., Kraemer, T., & Steuer, A. E. (2018). Time-dependent postmortem redistribution of opioids in blood and alternative matrices. Journal of Analytical Toxicology, 42(6), 365-374.
- 5. Case, A., & Deaton, A. (2017). Mortality and morbidity in the 21st century. Brookings papers on economic activity, 2017, 397.
- 6. Cash, R. E. (2018). Naloxone administration frequency during emergency medical service events—United States, 2012–2016. MMWR. Morbidity and mortality weekly report, 67.
- 7. Castillo, C., Steffens, T., Sim, L., & Caffery, L. (2021). The effect of clinical information on radiology reporting: a systematic review. Journal of medical radiation sciences, 68(1), 60-74.
- 8. Cederholm, T., Jensen, G. L., Correia, M. I. T. D., Gonzalez, M. C., Fukushima, R., Higashiguchi, T., ... & GLIM Core Leadership Committee, GLIM Working Group. (2019). GLIM criteria for the diagnosis of malnutrition–a consensus report from the global clinical nutrition community. Journal of cachexia, sarcopenia and muscle, 10(1), 207-217.
- 9. Ciccarone, D. (2019). The triple wave epidemic: supply and demand drivers of the US opioid overdose crisis. International Journal of Drug Policy, 71, 183-188.
- 10. Dasgupta, N., Beletsky, L., & Ciccarone, D. (2018). Opioid crisis: no easy fix to its social and economic determinants. American journal of public health, 108(2), 182-186.
- 11. Deng, J., Zhu, X., Chen, Z., Fan, C. H., Kwan, H. S., Wong, C. H., ... & Lam, T. N. (2017). A review of food–drug interactions on oral drug absorption. Drugs, 77(17), 1833-1855.
- 12. Dror, I. E. (2020). Cognitive and human factors in expert decision making: six fallacies and the eight sources of bias. Analytical chemistry, 92(12), 7998-8004.
- 13. Faul, M., Lurie, P., Kinsman, J. M., Dailey, M. W., Crabaugh, C., & Sasser, S. M. (2017). Multiple naloxone administrations among emergency medical service providers is increasing. Prehospital Emergency Care, 21(4), 411-419.
- 14. FitzGerald, C., & Hurst, S. (2017). Implicit bias in healthcare professionals: a systematic review. BMC medical ethics, 18(1), 19.
- 15. Friedman, J., & Shover, C. L. (2023). Charting the fourth wave: Geographic, temporal, race/ethnicity and demographic trends in polysubstance fentanyl overdose deaths in the United States, 2010–2021. Addiction, 118(12), 2477-2485.
- 16. Gundersen, C., & Ziliak, J. P. (2018). Food insecurity research in the United States: where we have been and where we need to go. Applied Economic Perspectives and Policy, 40(1), 119-135.
- 17. Hedegaard, H., Miniño, A. M., Spencer, M. R., & Warner, M. (2021). Drug overdose deaths in the United States, 1999–2020.
- 18. Jones, C. M., Einstein, E. B., & Compton, W. M. (2018). Changes in synthetic opioid involvement in drug overdose deaths in the United States, 2010-2016. Jama, 319(17), 1819-1821.
- 19. Krotulski, A. J., Papsun, D. M., Kacinko, S. L., & Logan, B. K. (2020). Isotonitazene quantitation and metabolite discovery in authentic forensic casework. Journal of Analytical Toxicology, 44(6), 521-530.
- 20. Maghsoudi, N., Tanguay, J., Scarfone, K., Rammohan, I., Ziegler, C., Werb, D., & Scheim, A. I. (2022). Drug checking services for people who use drugs: a systematic review. Addiction, 117(3), 532-544.
- 21. Magnan, S. (2017). Social determinants of health 101 for health care: five plus five. NAM perspectives.
- 22. Mattson, C. L. (2021). Trends and geographic patterns in drug and synthetic opioid overdose deaths—United States, 2013–2019. MMWR. Morbidity and mortality weekly report, 70.
- 23. Mell, H. K., Mumma, S. N., Hiestand, B., Carr, B. G., Holland, T., & Stopyra, J. (2017). Emergency medical services response times in rural, suburban, and urban areas. JAMA surgery, 152(10), 983-984.
- 24. Merz, F. (2018). United Nations Office on Drugs and Crime: World Drug Report 2017. 2017. SIRIUS-Zeitschrift für Strategische Analysen, 2(1), 85-86.
- 25. Moy, A. J., Schwartz, J. M., Chen, R., Sadri, S., Lucas, E., Cato, K. D., & Rossetti, S. C. (2021). Measurement of clinical documentation burden among physicians and nurses using electronic health records: a scoping review. Journal of the American Medical Informatics Association, 28(5), 998-1008.
- 26. Newman-Toker, D. E., Wang, Z., Zhu, Y., Nassery, N., Tehrani, A. S. S., Schaffer, A. C., ... & Siegal, D. (2021). Rate of diagnostic errors and serious misdiagnosis-related harms for major vascular events, infections, and cancers: toward a national incidence estimate using the “Big Three”. Diagnosis, 8(1), 67-84.
- 27. Papsun, D. M., Krotulski, A. J., & Logan, B. K. (2022). Proliferation of novel synthetic opioids in postmortem investigations after core-structure scheduling for fentanyl-related substances. The American Journal of Forensic Medicine and Pathology, 43(4), 315-327.
- 28. Pasin, D., Cawley, A., Bidny, S., & Fu, S. (2017). Current applications of high-resolution mass spectrometry for the analysis of new psychoactive substances: a critical review: D. Pasin et al. Analytical and bioanalytical chemistry, 409(25), 5821-5836.
- 29. Peacock, A., Bruno, R., Gisev, N., Degenhardt, L., Hall, W., Sedefov, R., ... & Griffiths, P. (2019). New psychoactive substances: challenges for drug surveillance, control, and public health responses. The Lancet, 394(10209), 1668-1684.
- 30. Reeves, S. (2018). Interprofessional collaboration to improve professional practice and healthcare outcomes. Cochrane Database Syst Rev, 8, Cd000072.
- 31. Rutty, G. N., Morgan, B., Robinson, C., Raj, V., Pakkal, M., Amoroso, J., ... & Hew, R. (2017). Diagnostic accuracy of post-mortem CT with targeted coronary angiography versus autopsy for coroner-requested post-mortem investigations: a prospective, masked, comparison study. The Lancet, 390(10090), 145-154.
- 32. Rzasa Lynn, R., & Galinkin, J. L. (2018). Naloxone dosage for opioid reversal: current evidence and clinical implications. Therapeutic advances in drug safety, 9(1), 63-88.
- 33. Slavova, S., Costich, J. F., Bunn, T. L., Luu, H., Singleton, M., Hargrove, S. L., ... & Ingram, V. (2017). Heroin and fentanyl overdoses in Kentucky: Epidemiology and surveillance. International Journal of Drug Policy, 46, 120-129.
- 34. Spencer, M. R., Warner, M., Bastian, B. A., Trinidad, J. P., & Hedegaard, H. (2019). Drug overdose deaths involving fentanyl, 2011–2016.
- 35. Sutton, R. T., Pincock, D., Baumgart, D. C., Sadowski, D. C., Fedorak, R. N., & Kroeker, K. I. (2020). An overview of clinical decision support systems: benefits, risks, and strategies for success. NPJ digital medicine, 3(1), 17.
- 36. Tasew, H., Mariye, T., & Teklay, G. (2019). Nursing documentation practice and associated factors among nurses in public hospitals, Tigray, Ethiopia. BMC research notes, 12(1), 612.
- 37. Torralva, R., & Janowsky, A. (2019). Noradrenergic mechanisms in fentanyl-mediated rapid death explain failure of naloxone in the opioid crisis. The Journal of pharmacology and experimental therapeutics, 371(2), 453-475.
- 38. Ulwelling, W., & Smith, K. (2018). The PEth blood test in the security environment: what it is; why it is important; and interpretative guidelines. Journal of forensic sciences, 63(6), 1634-1640.
- 39. Valentine, J. L., Sekula, L. K., & Lynch, V. (2020). Evolution of forensic nursing theory——Introduction of the constructed theory of forensic nursing care: A middle-range theory. Journal of forensic nursing, 16(4), 188.
- 40. Volkow, N. D., Gordon, J. A., & Koob, G. F. (2021). Choosing appropriate language to reduce the stigma around mental illness and substance use disorders. Neuropsychopharmacology, 46(13), 2230-2232.
- 41. Wakeman, S. E., Larochelle, M. R., Ameli, O., Chaisson, C. E., McPheeters, J. T., Crown, W. H., ... & Sanghavi, D. M. (2020). Comparative effectiveness of different treatment pathways for opioid use disorder. JAMA network open, 3(2), e1920622.
- 42. Wille, S. M. R., Richeval, C., Nachon‐Phanithavong, M., Gaulier, J. M., Di Fazio, V., Humbert, L., ... & Allorge, D. (2018). Prevalence of new psychoactive substances and prescription drugs in the Belgian driving under the influence of drugs population. Drug testing and analysis, 10(3), 539-547.
- 43. Zimmermann, M., Zimmermann-Kogadeeva, M., Wegmann, R., & Goodman, A. L. (2019). Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature, 570(7762), 462-467.
References
1. Akhu‐Zaheya, L., Al‐Maaitah, R., & Bany Hani, S. (2018). Quality of nursing documentation: Paper‐based health records versus electronic‐based health records. Journal of clinical nursing, 27(3-4), e578-e589.
2. Anderson, L. J., Flynn, A., & Pilgrim, J. L. (2017). A global epidemiological perspective on the toxicology of drug-facilitated sexual assault: A systematic review. Journal of forensic and legal medicine, 47, 46-54.
3. Blanco, C., Wiley, T. R., Lloyd, J. J., Lopez, M. F., & Volkow, N. D. (2020). America’s opioid crisis: the need for an integrated public health approach. Translational psychiatry, 10(1), 167.
4. Brockbals, L., Staeheli, S. N., Gascho, D., Ebert, L. C., Kraemer, T., & Steuer, A. E. (2018). Time-dependent postmortem redistribution of opioids in blood and alternative matrices. Journal of Analytical Toxicology, 42(6), 365-374.
5. Case, A., & Deaton, A. (2017). Mortality and morbidity in the 21st century. Brookings papers on economic activity, 2017, 397.
6. Cash, R. E. (2018). Naloxone administration frequency during emergency medical service events—United States, 2012–2016. MMWR. Morbidity and mortality weekly report, 67.
7. Castillo, C., Steffens, T., Sim, L., & Caffery, L. (2021). The effect of clinical information on radiology reporting: a systematic review. Journal of medical radiation sciences, 68(1), 60-74.
8. Cederholm, T., Jensen, G. L., Correia, M. I. T. D., Gonzalez, M. C., Fukushima, R., Higashiguchi, T., ... & GLIM Core Leadership Committee, GLIM Working Group. (2019). GLIM criteria for the diagnosis of malnutrition–a consensus report from the global clinical nutrition community. Journal of cachexia, sarcopenia and muscle, 10(1), 207-217.
9. Ciccarone, D. (2019). The triple wave epidemic: supply and demand drivers of the US opioid overdose crisis. International Journal of Drug Policy, 71, 183-188.
10. Dasgupta, N., Beletsky, L., & Ciccarone, D. (2018). Opioid crisis: no easy fix to its social and economic determinants. American journal of public health, 108(2), 182-186.
11. Deng, J., Zhu, X., Chen, Z., Fan, C. H., Kwan, H. S., Wong, C. H., ... & Lam, T. N. (2017). A review of food–drug interactions on oral drug absorption. Drugs, 77(17), 1833-1855.
12. Dror, I. E. (2020). Cognitive and human factors in expert decision making: six fallacies and the eight sources of bias. Analytical chemistry, 92(12), 7998-8004.
13. Faul, M., Lurie, P., Kinsman, J. M., Dailey, M. W., Crabaugh, C., & Sasser, S. M. (2017). Multiple naloxone administrations among emergency medical service providers is increasing. Prehospital Emergency Care, 21(4), 411-419.
14. FitzGerald, C., & Hurst, S. (2017). Implicit bias in healthcare professionals: a systematic review. BMC medical ethics, 18(1), 19.
15. Friedman, J., & Shover, C. L. (2023). Charting the fourth wave: Geographic, temporal, race/ethnicity and demographic trends in polysubstance fentanyl overdose deaths in the United States, 2010–2021. Addiction, 118(12), 2477-2485.
16. Gundersen, C., & Ziliak, J. P. (2018). Food insecurity research in the United States: where we have been and where we need to go. Applied Economic Perspectives and Policy, 40(1), 119-135.
17. Hedegaard, H., Miniño, A. M., Spencer, M. R., & Warner, M. (2021). Drug overdose deaths in the United States, 1999–2020.
18. Jones, C. M., Einstein, E. B., & Compton, W. M. (2018). Changes in synthetic opioid involvement in drug overdose deaths in the United States, 2010-2016. Jama, 319(17), 1819-1821.
19. Krotulski, A. J., Papsun, D. M., Kacinko, S. L., & Logan, B. K. (2020). Isotonitazene quantitation and metabolite discovery in authentic forensic casework. Journal of Analytical Toxicology, 44(6), 521-530.
20. Maghsoudi, N., Tanguay, J., Scarfone, K., Rammohan, I., Ziegler, C., Werb, D., & Scheim, A. I. (2022). Drug checking services for people who use drugs: a systematic review. Addiction, 117(3), 532-544.
21. Magnan, S. (2017). Social determinants of health 101 for health care: five plus five. NAM perspectives.
22. Mattson, C. L. (2021). Trends and geographic patterns in drug and synthetic opioid overdose deaths—United States, 2013–2019. MMWR. Morbidity and mortality weekly report, 70.
23. Mell, H. K., Mumma, S. N., Hiestand, B., Carr, B. G., Holland, T., & Stopyra, J. (2017). Emergency medical services response times in rural, suburban, and urban areas. JAMA surgery, 152(10), 983-984.
24. Merz, F. (2018). United Nations Office on Drugs and Crime: World Drug Report 2017. 2017. SIRIUS-Zeitschrift für Strategische Analysen, 2(1), 85-86.
25. Moy, A. J., Schwartz, J. M., Chen, R., Sadri, S., Lucas, E., Cato, K. D., & Rossetti, S. C. (2021). Measurement of clinical documentation burden among physicians and nurses using electronic health records: a scoping review. Journal of the American Medical Informatics Association, 28(5), 998-1008.
26. Newman-Toker, D. E., Wang, Z., Zhu, Y., Nassery, N., Tehrani, A. S. S., Schaffer, A. C., ... & Siegal, D. (2021). Rate of diagnostic errors and serious misdiagnosis-related harms for major vascular events, infections, and cancers: toward a national incidence estimate using the “Big Three”. Diagnosis, 8(1), 67-84.
27. Papsun, D. M., Krotulski, A. J., & Logan, B. K. (2022). Proliferation of novel synthetic opioids in postmortem investigations after core-structure scheduling for fentanyl-related substances. The American Journal of Forensic Medicine and Pathology, 43(4), 315-327.
28. Pasin, D., Cawley, A., Bidny, S., & Fu, S. (2017). Current applications of high-resolution mass spectrometry for the analysis of new psychoactive substances: a critical review: D. Pasin et al. Analytical and bioanalytical chemistry, 409(25), 5821-5836.
29. Peacock, A., Bruno, R., Gisev, N., Degenhardt, L., Hall, W., Sedefov, R., ... & Griffiths, P. (2019). New psychoactive substances: challenges for drug surveillance, control, and public health responses. The Lancet, 394(10209), 1668-1684.
30. Reeves, S. (2018). Interprofessional collaboration to improve professional practice and healthcare outcomes. Cochrane Database Syst Rev, 8, Cd000072.
31. Rutty, G. N., Morgan, B., Robinson, C., Raj, V., Pakkal, M., Amoroso, J., ... & Hew, R. (2017). Diagnostic accuracy of post-mortem CT with targeted coronary angiography versus autopsy for coroner-requested post-mortem investigations: a prospective, masked, comparison study. The Lancet, 390(10090), 145-154.
32. Rzasa Lynn, R., & Galinkin, J. L. (2018). Naloxone dosage for opioid reversal: current evidence and clinical implications. Therapeutic advances in drug safety, 9(1), 63-88.
33. Slavova, S., Costich, J. F., Bunn, T. L., Luu, H., Singleton, M., Hargrove, S. L., ... & Ingram, V. (2017). Heroin and fentanyl overdoses in Kentucky: Epidemiology and surveillance. International Journal of Drug Policy, 46, 120-129.
34. Spencer, M. R., Warner, M., Bastian, B. A., Trinidad, J. P., & Hedegaard, H. (2019). Drug overdose deaths involving fentanyl, 2011–2016.
35. Sutton, R. T., Pincock, D., Baumgart, D. C., Sadowski, D. C., Fedorak, R. N., & Kroeker, K. I. (2020). An overview of clinical decision support systems: benefits, risks, and strategies for success. NPJ digital medicine, 3(1), 17.
36. Tasew, H., Mariye, T., & Teklay, G. (2019). Nursing documentation practice and associated factors among nurses in public hospitals, Tigray, Ethiopia. BMC research notes, 12(1), 612.
37. Torralva, R., & Janowsky, A. (2019). Noradrenergic mechanisms in fentanyl-mediated rapid death explain failure of naloxone in the opioid crisis. The Journal of pharmacology and experimental therapeutics, 371(2), 453-475.
38. Ulwelling, W., & Smith, K. (2018). The PEth blood test in the security environment: what it is; why it is important; and interpretative guidelines. Journal of forensic sciences, 63(6), 1634-1640.
39. Valentine, J. L., Sekula, L. K., & Lynch, V. (2020). Evolution of forensic nursing theory——Introduction of the constructed theory of forensic nursing care: A middle-range theory. Journal of forensic nursing, 16(4), 188.
40. Volkow, N. D., Gordon, J. A., & Koob, G. F. (2021). Choosing appropriate language to reduce the stigma around mental illness and substance use disorders. Neuropsychopharmacology, 46(13), 2230-2232.
41. Wakeman, S. E., Larochelle, M. R., Ameli, O., Chaisson, C. E., McPheeters, J. T., Crown, W. H., ... & Sanghavi, D. M. (2020). Comparative effectiveness of different treatment pathways for opioid use disorder. JAMA network open, 3(2), e1920622.
42. Wille, S. M. R., Richeval, C., Nachon‐Phanithavong, M., Gaulier, J. M., Di Fazio, V., Humbert, L., ... & Allorge, D. (2018). Prevalence of new psychoactive substances and prescription drugs in the Belgian driving under the influence of drugs population. Drug testing and analysis, 10(3), 539-547.
43. Zimmermann, M., Zimmermann-Kogadeeva, M., Wegmann, R., & Goodman, A. L. (2019). Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature, 570(7762), 462-467.