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Copyright (c) 2024 Fadhel Alhakeem, Adel Ahmed Harthi, Hajah Mohamad Azybi, Ahlam Mohammed Almotire, Nawal Ali Mohd Walby, Hajar Marzouq Alharbi, Ahmad Rodiman Alenezi, Rizq Mohammad Ahmad Alrajhi, Abdullah Ali Hussain Mobarki, Ahmed Salem Mohammed Al-Harthi, Ahmed Nasserallah Al-Miskeen

This work is licensed under a Creative Commons Attribution 4.0 International License.
Artificial Intelligence–Enabled Multidisciplinary Surgical Care: Integrating Laboratory Diagnostics, Radiology, Pharmacy, Nursing, Operating Room Practice, and Oral–Maxillofacial Surgery
Corresponding Author(s) : Fadhel Alhakeem
Saudi Journal of Medicine and Public Health, Vol. 1 No. 2 (2024)
Abstract
Artificial intelligence (AI) is reshaping surgical care across multiple disciplines, yet integration remains fragmented. This narrative review synthesizes evidence (2016–2024) on AI applications spanning laboratory diagnostics, radiology, pharmacy, nursing, operating room practice, and oral–maxillofacial surgery. AI enhances laboratory quality control and predictive analytics, improves radiological segmentation and three-dimensional surgical planning, supports perioperative medication safety through clinical decision support, augments nursing surveillance and operating room teamwork, and demonstrates diagnostic and prognostic utility in oral–maxillofacial surgery. However, translation is constrained by data heterogeneity, algorithmic opacity, workflow misalignment, and absent integration architectures. Central command suite concepts offer a unifying framework. This review argues that AI should function as a connective layer across surgical disciplines, preserving clinician oversight while enabling multidisciplinary data synthesis and real-time decision support.
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- 1. Adegbesan, A., Akingbola, A., Aremu, O., Adewole, O., Amamdikwa, J. C., & Shagaya, U. (2024). From scalpels to algorithms: the risk of dependence on artificial intelligence in surgery. Journal of Medicine, Surgery, and Public Health, 3, 100140. https://doi.org/10.1016/j.glmedi.2024.100140
- 2. Adewusi, B. A., Adekunle, B. I., Mustapha, S. D., & Uzoka, A. C. (2023). Advances in AI-augmented user experience design for personalized public and enterprise digital services. DOI: https://doi. org/10.62225 X, 2583049.
- 3. Ahmad, O. F., Stoyanov, D., & Lovat, L. B. (2020). Barriers and pitfalls for artificial intelligence in gastroenterology: ethical and regulatory issues. Techniques and Innovations in Gastrointestinal Endoscopy, 22(2), 80-84. https://doi.org/10.1016/j.tgie.2019.150636
- 4. Ahmed, N., Abbasi, M. S., Zuberi, F., Qamar, W., Halim, M. S. B., Maqsood, A., & Alam, M. K. (2021). Artificial intelligence techniques: analysis, application, and outcome in dentistry—a systematic review. BioMed research international, 2021(1), 9751564. https://doi.org/10.1155/2021/9751564
- 5. Ahmad, A., Tariq, A., Hussain, H. K., & Gill, A. Y. (2023). Equity and artificial intelligence in surgical care: A comprehensive review of current challenges and promising solutions. BULLET: Jurnal Multidisiplin Ilmu, 2(2), 443-455.
- 6. Bellini, V., Valente, M., Del Rio, P., & Bignami, E. (2021). Artificial intelligence in thoracic surgery: a narrative review. Journal of Thoracic Disease, 13(12), 6963. https://doi.org/10.21037/jtd-21-761
- 7. Bozzo, A., Tsui, J. M., Bhatnagar, S., & Forsberg, J. (2024). Deep learning and multimodal artificial intelligence in orthopaedic surgery. The Journal of the American Academy of Orthopaedic Surgeons, 32(11), e523. https://doi.org/10.5435/JAAOS-D-23-00831
- 8. Brydges, G., Uppal, A., & Gottumukkala, V. (2024). Application of machine learning in predicting perioperative outcomes in patients with cancer: A narrative review for clinicians. Current Oncology, 31(5), 2727-2747. https://doi.org/10.3390/curroncol31050207
- 9. Byrd IV, T. F., & Tignanelli, C. J. (2024). Artificial intelligence in surgery—a narrative review. Journal of Medical Artificial Intelligence, 7, 29. DOI: 10.21037/jmai-24-111
- 10. Cai, J., Li, P., Li, W., & Zhu, T. (2024). Outcomes of clinical decision support systems in real-world perioperative care: a systematic review and meta-analysis. International journal of surgery (London, England), 110(12), 8057. https://doi.org/10.1097/JS9.0000000000001821
- 11. Cunha Reis, T. (2024). The roadblocks to AI adoption in surgery: Data, real‐time applications and ethics. Medicine Advances, 2(4), 380-383. DOI: 10.1002/med4.82
- 12. Czako, L., Sufliarsky, B., Simko, K., Sovis, M., Vidova, I., Farska, J., ... & Galis, B. (2024). Exploring the practical applications of artificial intelligence, deep learning, and machine learning in maxillofacial surgery: a comprehensive analysis of published works. Bioengineering, 11(7), 679. https://doi.org/10.3390/bioengineering11070679
- 13. Dias, R. D. (2022). Collaborative Research: SCH: An AI Coach to Enhance Surgical Teamwork in the Cardiac Operating Room. NSF Award Number 2204850. Directorate for Computer and Information Science and Engineering, 22(2204850), 4850.
- 14. Dong, F., Yan, J., Zhang, X., Zhang, Y., Liu, D., Pan, X., ... & Liu, Y. (2024). Artificial intelligence-based predictive model for guidance on treatment strategy selection in oral and maxillofacial surgery. Heliyon, 10(15). https://doi.org/10.1016/j.heliyon.2024.e35742
- 15. Etienne, H., Hamdi, S., Le Roux, M., Camuset, J., Khalife-Hocquemiller, T., Giol, M., ... & Assouad, J. (2020). Artificial intelligence in thoracic surgery: past, present, perspective and limits. European Respiratory Review, 29(157), 200010. https://doi.org/10.1183/16000617.0010-2020
- 16. Fischer, L. (2024). Applying artificial intelligence to perioperative nursing practice. AORN journal, 119(6), P1-P4. https://doi.org/10.1002/aorn.14156
- 17. Hassan, A. M., Rajesh, A., Asaad, M., Nelson, J. A., Coert, J. H., Mehrara, B. J., & Butler, C. E. (2023). Artificial intelligence and machine learning in prediction of surgical complications: current state, applications, and implications. The American Surgeon, 89(1), 25-30. https://doi.org/10.1177/00031348221101488
- 18. Hasan, M. (2024). Applications of artificial intelligence in drug discovery and pharmacy practice: a review (Doctoral dissertation, BRAC University).
- 19. Hung, K. F., Yeung, A. W. K., Bornstein, M. M., & Schwendicke, F. (2023). Personalized dental medicine, artificial intelligence, and their relevance for dentomaxillofacial imaging. Dentomaxillofacial Radiology, 52(1), 20220335. https://doi.org/10.1259/dmfr.20220335
- 20. Hussain, H. K., Tariq, A., Gill, A. Y., & Ahmad, A. (2022). Transforming healthcare: The rapid rise of artificial intelligence revolutionizing healthcare applications. BULLET: Jurnal Multidisiplin Ilmu, 1(02), 592216.
- 21. Khizir, L., Bhandari, V., Kaloth, S., Pfail, J., Lichtbroun, B., Yanamala, N., & Elsamra, S. E. (2024). From diagnosis to precision surgery: The transformative role of artificial intelligence in urologic imaging. Journal of endourology, 38(8), 824-835. https://doi.org/10.1089/end.2023.0695
- 22. Mithany, R. H., Aslam, S., Abdallah, S., Abdelmaseeh, M., Gerges, F., Mohamed, M. S., ... & Daniel, N. (2023). Advancements and challenges in the application of artificial intelligence in surgical arena: a literature review. Cureus, 15(10). DOI: 10.7759/cureus.47924
- 23. Mohaideen, K., Negi, A., Verma, D. K., Kumar, N., Sennimalai, K., & Negi, A. (2022). Applications of artificial intelligence and machine learning in orthognathic surgery: A scoping review. Journal of Stomatology, Oral and Maxillofacial Surgery, 123(6), e962-e972. https://doi.org/10.1016/j.jormas.2022.06.027
- 24. Motie, P., Hemmati, G., Hazrati, P., Lazar, M., Varzaneh, F. A., Mohammad-Rahimi, H., ... & Motamedian, S. R. (2023). Application of artificial intelligence in diagnosing oral and maxillofacial lesions, facial corrective surgeries, and maxillofacial reconstructive procedures. In Emerging Technologies in Oral and Maxillofacial Surgery (pp. 287-328). Singapore: Springer Nature Singapore. https://doi.org/10.1007/978-981-19-8602-4_15
- 25. Padmanabhan, P. (2017). The Big Unlock: Harnessing Data and Growing Digital Health Businesses in a Value-Based Care Era. Archway Publishing.
- 26. Paiste, H. J., Godwin, R. C., Smith, A. D., Berkowitz, D. E., & Melvin, R. L. (2024). Strengths-weaknesses-opportunities-threats analysis of artificial intelligence in anesthesiology and perioperative medicine. Frontiers in Digital Health, 6, 1316931. https://doi.org/10.3389/fdgth.2024.1316931
- 27. Pereira, K. R. (2021). Harnessing artificial intelligence in maxillofacial surgery. In Artificial Intelligence in Medicine (pp. 1-19). Cham: Springer International Publishing. https://doi.org/10.1007/978-3-030-58080-3_322-1#DOI
- 28. Quero, G., Mascagni, P., Kolbinger, F. R., Fiorillo, C., De Sio, D., Longo, F., ... & Alfieri, S. (2022). Artificial intelligence in colorectal cancer surgery: present and future perspectives. Cancers, 14(15), 3803. https://doi.org/10.3390/cancers14153803
- 29. Rafaih, A. B., & Ari, K. (2024). Artificial intelligence-driven approaches to managing surgeon fatigue and improving performance. Cureus, 16(12), e75717-e75717.
- 30. Rasteau, S., Ernenwein, D., Savoldelli, C., & Bouletreau, P. (2022). Artificial intelligence for oral and maxillo-facial surgery: A narrative review. Journal of stomatology, oral and maxillofacial surgery, 123(3), 276-282. https://doi.org/10.1016/j.jormas.2022.01.010
- 31. Ren, R., Luo, H., Su, C., Yao, Y., & Liao, W. (2021). Machine learning in dental, oral and craniofacial imaging: a review of recent progress. PeerJ, 9, e11451. https://doi.org/10.7717/peerj.11451
- 32. Siddiqui, T. A., Sukhia, R. H., & Ghandhi, D. (2022). Artificial intelligence in dentistry, orthodontics and Orthognathic surgery: A literature review. ournal of the Pakistan Medical Association, 72(2), 91-96.
- Available at: https://ecommons.aku.edu/pakistan_fhs_mc_surg_dent_oral_maxillofac/201
- 33. Thacharodi, A., Singh, P., Meenatchi, R., Tawfeeq Ahmed, Z. H., Kumar, R. R., V, N., ... & Hassan, S. (2024). Revolutionizing healthcare and medicine: The impact of modern technologies for a healthier future—A comprehensive review. Health care science, 3(5), 329-349. https://doi.org/10.1002/hcs2.115
- 34. Thai, M. T., Phan, P. T., Hoang, T. T., Wong, S., Lovell, N. H., & Do, T. N. (2020). Advanced intelligent systems for surgical robotics. Advanced Intelligent Systems, 2(8), 1900138. https://doi.org/10.1002/aisy.201900138
- 35. Van der Meijden, S. L., Arbous, M. S., & Geerts, B. F. (2023). Possibilities and challenges for artificial intelligence and machine learning in perioperative care. BJA education, 23(8), 288-294. https://doi.org/10.1016/j.bjae.2023.04.003
- 36. Varghese, C., Harrison, E. M., O’Grady, G., & Topol, E. J. (2024). Artificial intelligence in surgery. Nature medicine, 30(5), 1257-1268. https://doi.org/10.1038/s41591-024-02970-3
- 37. Wabro, A., & Herrmann, M. (2024). When time is of the essence-ethical implications of XAI in surgical oncology: 891. Oncology Research and Treatment, 47, 24.
- 38. Williams, S., Layard Horsfall, H., Funnell, J. P., Hanrahan, J. G., Khan, D. Z., Muirhead, W., ... & Marcus, H. J. (2021). Artificial intelligence in brain tumour surgery—an emerging paradigm. Cancers, 13(19), 5010. https://doi.org/10.3390/cancers13195010
- 39. Xie, H., Jia, Y., & Liu, S. (2024). Integration of artificial intelligence in clinical laboratory medicine: Advancements and challenges. Interdisciplinary Medicine, 2(3), e20230056. https://doi.org/10.1002/INMD.20230056
- 40. Yan, K. X., Liu, L., & Li, H. (2021). Application of machine learning in oral and maxillofacial surgery. Artificial Intelligence in Medical Imaging, 2(6), 104-114. http://dx.doi.org/10.35711/aimi.v2.i6.104
- 41. Zhang, Y., Weng, Y., & Lund, J. (2022). Applications of explainable artificial intelligence in diagnosis and surgery. Diagnostics, 12(2), 237. https://doi.org/10.3390/diagnostics12020237
- 42. Zeng, J., & Fu, Q. (2024). A review: artificial intelligence in image-guided spinal surgery. Expert Review of Medical Devices, 21(8), 689-700. https://doi.org/10.1080/17434440.2024.2384541
References
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21. Khizir, L., Bhandari, V., Kaloth, S., Pfail, J., Lichtbroun, B., Yanamala, N., & Elsamra, S. E. (2024). From diagnosis to precision surgery: The transformative role of artificial intelligence in urologic imaging. Journal of endourology, 38(8), 824-835. https://doi.org/10.1089/end.2023.0695
22. Mithany, R. H., Aslam, S., Abdallah, S., Abdelmaseeh, M., Gerges, F., Mohamed, M. S., ... & Daniel, N. (2023). Advancements and challenges in the application of artificial intelligence in surgical arena: a literature review. Cureus, 15(10). DOI: 10.7759/cureus.47924
23. Mohaideen, K., Negi, A., Verma, D. K., Kumar, N., Sennimalai, K., & Negi, A. (2022). Applications of artificial intelligence and machine learning in orthognathic surgery: A scoping review. Journal of Stomatology, Oral and Maxillofacial Surgery, 123(6), e962-e972. https://doi.org/10.1016/j.jormas.2022.06.027
24. Motie, P., Hemmati, G., Hazrati, P., Lazar, M., Varzaneh, F. A., Mohammad-Rahimi, H., ... & Motamedian, S. R. (2023). Application of artificial intelligence in diagnosing oral and maxillofacial lesions, facial corrective surgeries, and maxillofacial reconstructive procedures. In Emerging Technologies in Oral and Maxillofacial Surgery (pp. 287-328). Singapore: Springer Nature Singapore. https://doi.org/10.1007/978-981-19-8602-4_15
25. Padmanabhan, P. (2017). The Big Unlock: Harnessing Data and Growing Digital Health Businesses in a Value-Based Care Era. Archway Publishing.
26. Paiste, H. J., Godwin, R. C., Smith, A. D., Berkowitz, D. E., & Melvin, R. L. (2024). Strengths-weaknesses-opportunities-threats analysis of artificial intelligence in anesthesiology and perioperative medicine. Frontiers in Digital Health, 6, 1316931. https://doi.org/10.3389/fdgth.2024.1316931
27. Pereira, K. R. (2021). Harnessing artificial intelligence in maxillofacial surgery. In Artificial Intelligence in Medicine (pp. 1-19). Cham: Springer International Publishing. https://doi.org/10.1007/978-3-030-58080-3_322-1#DOI
28. Quero, G., Mascagni, P., Kolbinger, F. R., Fiorillo, C., De Sio, D., Longo, F., ... & Alfieri, S. (2022). Artificial intelligence in colorectal cancer surgery: present and future perspectives. Cancers, 14(15), 3803. https://doi.org/10.3390/cancers14153803
29. Rafaih, A. B., & Ari, K. (2024). Artificial intelligence-driven approaches to managing surgeon fatigue and improving performance. Cureus, 16(12), e75717-e75717.
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31. Ren, R., Luo, H., Su, C., Yao, Y., & Liao, W. (2021). Machine learning in dental, oral and craniofacial imaging: a review of recent progress. PeerJ, 9, e11451. https://doi.org/10.7717/peerj.11451
32. Siddiqui, T. A., Sukhia, R. H., & Ghandhi, D. (2022). Artificial intelligence in dentistry, orthodontics and Orthognathic surgery: A literature review. ournal of the Pakistan Medical Association, 72(2), 91-96.
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_surg_dent_oral_maxillofac/201
33. Thacharodi, A., Singh, P., Meenatchi, R., Tawfeeq Ahmed, Z. H., Kumar, R. R., V, N., ... & Hassan, S. (2024). Revolutionizing healthcare and medicine: The impact of modern technologies for a healthier future—A comprehensive review. Health care science, 3(5), 329-349. https://doi.org/10.1002/hcs2.115
34. Thai, M. T., Phan, P. T., Hoang, T. T., Wong, S., Lovell, N. H., & Do, T. N. (2020). Advanced intelligent systems for surgical robotics. Advanced Intelligent Systems, 2(8), 1900138. https://doi.org/10.1002/aisy.201900138
35. Van der Meijden, S. L., Arbous, M. S., & Geerts, B. F. (2023). Possibilities and challenges for artificial intelligence and machine learning in perioperative care. BJA education, 23(8), 288-294. https://doi.org/10.1016/j.bjae.2023.04.003
36. Varghese, C., Harrison, E. M., O’Grady, G., & Topol, E. J. (2024). Artificial intelligence in surgery. Nature medicine, 30(5), 1257-1268. https://doi.org/10.1038/s41591-024-02970-3
37. Wabro, A., & Herrmann, M. (2024). When time is of the essence-ethical implications of XAI in surgical oncology: 891. Oncology Research and Treatment, 47, 24.
38. Williams, S., Layard Horsfall, H., Funnell, J. P., Hanrahan, J. G., Khan, D. Z., Muirhead, W., ... & Marcus, H. J. (2021). Artificial intelligence in brain tumour surgery—an emerging paradigm. Cancers, 13(19), 5010. https://doi.org/10.3390/cancers13195010
39. Xie, H., Jia, Y., & Liu, S. (2024). Integration of artificial intelligence in clinical laboratory medicine: Advancements and challenges. Interdisciplinary Medicine, 2(3), e20230056. https://doi.org/10.1002/INMD.20230056
40. Yan, K. X., Liu, L., & Li, H. (2021). Application of machine learning in oral and maxillofacial surgery. Artificial Intelligence in Medical Imaging, 2(6), 104-114. http://dx.doi.org/10.35711/aimi.v2.i6.104
41. Zhang, Y., Weng, Y., & Lund, J. (2022). Applications of explainable artificial intelligence in diagnosis and surgery. Diagnostics, 12(2), 237. https://doi.org/10.3390/diagnostics12020237
42. Zeng, J., & Fu, Q. (2024). A review: artificial intelligence in image-guided spinal surgery. Expert Review of Medical Devices, 21(8), 689-700. https://doi.org/10.1080/17434440.2024.2384541