Containing the Silent Pandemic: A Narrative Review of a One-Health Approach to Antimicrobial Resistance from Laboratory to Bedside to Community
Abstract
Background: Antimicrobial resistance (AMR) is a quintessential "One Health" crisis, propelled by interconnected drivers in human, animal, and environmental ecosystems. Containing AMR demands an integrated, multidisciplinary response that transcends traditional silos in healthcare delivery. Aim: This narrative review synthesizes evidence from 2015-2024 to analyze a coordinated AMR containment framework integrating the roles of laboratory science, epidemiology, pharmacy, radiology, nursing, community health, and health administration. Methods: A systematic search of PubMed, Scopus, CINAHL, and Web of Science informed a narrative synthesis of themes including rapid diagnostics, stewardship interventions, infection prevention, surveillance, and public engagement. Results: Evidence confirms that fragmented efforts are ineffective. Success hinges on laboratory-driven rapid diagnostics guiding pharmacist-led antimicrobial stewardship at the bedside, underpinned by nursing-led infection prevention. Radiology provides critical diagnostic and therapeutic support, while public health and administration build population-level surveillance and enable policy. Key barriers include diagnostic access disparities, interprofessional communication gaps, and conflicting economic incentives. Conclusion: AMR is a systems failure requiring a systems solution. A proactive, integrated One-Health model, where data seamlessly flows from the community to the lab and back to the point of care, is essential to preserve antimicrobial efficacy. Future efforts must prioritize interoperable data systems, standardized metrics, and economic models that reward stewardship.
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References
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Authors
Copyright (c) 2024 Hanan Hamood Ahmed Alshelely, Ibrahim Mohamed Hamed Somaily, Ali Sawailh Madah Alanaze, Naif Ali Hadi Harbi, Mousa Mohammed Abuhaselah, Hussain Ali Al Zaid, Mutlaq Musayyab M Alotaibi, Ebtisam Ahmed Alshehri, Ali Ibrahim Qasem, Yahya Mohammed Mutawam, Noora Saad Aldrehim, Muteb Salmen Sadon Almutaire, Sami Saeed Alrashdi, Haya Thafer Mohammed Althafer, Sami Saeed Alrashdi
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