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Copyright (c) 2025 Abdullah Mishal Almutairi, Prof. Mohammed A. Alsaif

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Assessment of The Long-Term Negative Impact of Bariatric Surgery on Health in Saudi Adults, over 3 Years after Surgery: A Cross-Sectional Study
Corresponding Author(s) : Abdullah Mishal Almutairi
Saudi Journal of Medicine and Public Health, Vol. 2 No. 2 (2025)
Abstract
Background: Bariatric surgery is a highly effective therapy for serious obesity. However, it has certain long-term complications that are due to deficiencies in nutrients, malabsorption, and weight loss. This study aimed to estimate the prevalence of long-term complications and associated factors after bariatric surgery among Saudi Arabian adults.
Methodology: A cross-sectional survey was conducted in Saudi Arabia between March 1-14, 2021. The sample was 497 subjects above 18 years of age, both sexes, and greater than 3 years post-bariatric surgery. A specially designed and validated online questionnaire was posted on social media.
Results: The sample was 495 subjects (36.6% male, 63.4% female). The average BMI upon study was 29.07. Frequent long-term complications included hair loss (68.5%), mood swings (50.5%), bone pain (43.8%), lethargy (41.2%), anemia (23.4%), and gallstone diagnosis (19.3%). Gallstone development had a significant association with a post-operative time of over 5 years (p=0.020). Bone pain (p=0.000) and muscle cramps (p=0.000) were reported by females than by males. Moreover, significant weight regain was observed in the subjects operated 5 or more years ago, with an average BMI of 31.48±7.351 (p=0.000).
Conclusion: This study indicates the high prevalence of long-term micronutrient deficiency symptoms and other associated health problems following bariatric surgery in the Saudi population despite presumed compliance with supplementation programs. Weight regain is also reported to be a significant problem after 5 years. The findings highlight the importance of intensive long-term follow-up, patient-centered nutritional management, and public education initiatives about the potential lifelong consequences of bariatric surgery.
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- M. Ng et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: A systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014;384(9945):766–781. doi: 10.1016/S0140-6736(14)60460-8.
- S. Kim. The Definition of Obesity. Korean J Fam Med. 2016;37:309. doi: 10.4082/kjfm.2016.37.6.309.
- G. M. Campos et al. Changes in utilization of bariatric surgery in the United States from 1993 to 2016. Ann Surg. 2020;271(2):201–209. doi: 10.1097/SLA.0000000000003554.
- S. S. M Alqarni. A Review of Prevalence of Obesity in Saudi Arabia. J Obes Eat Disord. 2016;02(02). doi: 10.21767/2471-8203.100025.
- Cutting the fat: More than 30,000 gastric sleeve surgeries in Saudi Arabia in 2020. Al Arabiya English. 14 Feb 2021. https://english.alarabiya.net/life-style/healthy-living/2021/02/14/Cutting-the-fat-More-than-30-000-gastric-sleeve-surgeries-in-Saudi-Arabia-in-2020 (accessed 26 Apr 2021).
- T. A. Alwasaidi et al. Determining the prevalence and causes of anaemia in patients after bariatric surgery in a Saudi hospital. J Taibah Univ Med Sci. 2020;15(2):129–135. doi: 10.1016/j.jtumed.2020.02.001.
- C. Gagnon, A. L. Schafer. Bone Health After Bariatric Surgery. JBMR Plus. 2018;2(3):121–133. doi: 10.1002/jbm4.10048.
- E. W. Gregg, J. E. Shaw. Global Health Effects of Overweight and Obesity. N Engl J Med. 2017;377(1):80–81. doi: 10.1056/nejme1706095.
- J. Bentham et al. Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults. Lancet. 2017;390(10113):2627–2642. doi: 10.1016/S0140-6736(17)32129-3.
- R. W. Alberca et al. Obesity as a risk factor for COVID-19: an overview. Crit Rev Food Sci Nutr. 2020;0(0):1–15. doi: 10.1080/10408398.2020.1775546.
- A. Hussain et al. Obesity and mortality of COVID-19. Meta-analysis. Obes Res Clin Pract. 2020;14(4):295–300. doi: 10.1016/j.orcp.2020.07.002.
- M. Tremmel et al. Economic burden of obesity: A systematic literature review. Int J Environ Res Public Health. 2017;14(4):1–18. doi: 10.3390/ijerph14040435.
- L. Angrisani et al. Bariatric Surgery Worldwide 2013. Obes Surg. 2015;25(10):1822–1832. doi: 10.1007/s11695-015-1657-z.
- A. Guirat et al. What is the role of the sleeve gastrectomy in the surgical treatment of morbid obesity? Eur Surg - Acta Chir Austriaca. 2014;46(5):181–188. doi: 10.1007/s10353-014-0285-5.
- J. Nudel, V. M. Sanchez. Surgical management of obesity. Metabolism. 2019;92:206–216. doi: 10.1016/j.metabol.2018.12.002.
- S. Karmali et al. Bariatric surgery: A primer. Can Fam Physician. 2010;56(9):873–879.
- G. Sanders, A. N. Kingsnorth. Gallstones. Br Med J. 2007;335(7614):295–299. doi: 10.1136/bmj.39267.452257.AD.
- D. J. Scott et al. Intraoperative ultrasound and prophylactic ursodiol for gallstone prevention following laparoscopic gastric bypass. Surg Endosc Other Interv Tech. 2003;17(11):1796–1802. doi: 10.1007/s00464-002-8930-7.
- A. E. Elshaer et al. Assessment of gallstones formation after bariatric surgery. Int Surg J. 2018;6(1):37. doi: 10.18203/2349-2902.isj20185120.
- M. M. Brzozowska et al. Bariatric surgery, bone loss, obesity and possible mechanisms. Obes Rev. 2013;14(1):52–67. doi: 10.1111/j.1467-789X.2012.01050.x.
- A. L. Schafer et al. Intestinal Calcium Absorption Decreases Dramatically after Gastric Bypass Surgery Despite Optimization of Vitamin D Status. J Bone Miner Res. 2015;30(8):1377–1385. doi: 10.1002/jbmr.2467.
- Z. Tian et al. Changes in Bone Metabolism After Sleeve Gastrectomy Versus Gastric Bypass: a Meta-Analysis. Obes Surg. 2020;30(1):77–86. doi: 10.1007/s11695-019-04119-5.
- S. Pellitero et al. Evaluation of Vitamin and Trace Element Requirements after Sleeve Gastrectomy at Long Term. Obes Surg. 2017;27(7):1674–1682. doi: 10.1007/s11695-017-2557-1.
- N. Polruang et al. Prevalence and incidence of iron deficiency in patients undergoing bariatric surgery: A teaching hospital experience in Thailand. J Med Assoc Thail. 2020;103(2):115–120.
- O. Jamil et al. Micronutrient deficiencies in laparoscopic sleeve gastrectomy. Nutrients. 2020;12(9):1–12. doi: 10.3390/nu12092896.
- C. S. Arhi et al. The Complex Association Between Bariatric Surgery and Depression: a National Nested-Control Study. Obes Surg. 2021. doi: 10.1007/s11695-020-05201-z.
- S. Alsubaie et al. Depression and anxiety on post-bariatric surgery among Saudi Adults residing in Abha, Asir Province, Saudi Arabia. Int J Med Dev Ctries. 2021;5(November 2020):165–171. doi: 10.24911/ijmdc.51-1605799192.
- E. Esnafoglu, D. D. Ozturan. The relationship of severity of depression with homocysteine, folate, vitamin B12, and vitamin D levels in children and adolescents. Child Adolesc Ment Health. 2020;25(4):249–255. doi: 10.1111/camh.12387.
- V. Menon et al. Vitamin D and Depression: A Critical Appraisal of the Evidence and Future Directions. Indian J Psychol Med. 2020;42(1):11–21. doi: 10.4103/IJPSYM.IJPSYM_160_19.
- S. Ledoux et al. What Are the Micronutrient Deficiencies Responsible for the Most Common Nutritional Symptoms After Bariatric Surgery? Obes Surg. 2020;30(5):1891–1897. doi: 10.1007/s11695-020-04412-8.
- A. Ukleja. Dumping Syndrome: pathophysiology and treatment. Nutr Clin Pract. 2005;20(5):517–525. doi: 10.1177/0115426505020005517.
- A. Poljo et al. Incidence of Dumping Syndrome after Sleeve Gastrectomy, Roux-en-Y Gastric Bypass and One-Anastomosis Gastric Bypass. pp. 1–13.
- D. Spirou, J. Raman, E. Smith. Psychological outcomes following surgical and endoscopic bariatric procedures: A systematic review. Obes Rev. 2020;21(6):1–24. doi: 10.1111/obr.12998.
- S. Ledoux, M. Flamant, D. Calabrese, C. Bogard, O. Sami, and M. Coupaye, “What Are the Micronutrient Deficiencies Responsible for the Most Common Nutritional Symptoms After Bariatric Surgery?,” Obes. Surg., vol. 30, no. 5, pp. 1891–1897, 2020, doi: 10.1007/s11695-020-04412-8.
References
M. Ng et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: A systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014;384(9945):766–781. doi: 10.1016/S0140-6736(14)60460-8.
S. Kim. The Definition of Obesity. Korean J Fam Med. 2016;37:309. doi: 10.4082/kjfm.2016.37.6.309.
G. M. Campos et al. Changes in utilization of bariatric surgery in the United States from 1993 to 2016. Ann Surg. 2020;271(2):201–209. doi: 10.1097/SLA.0000000000003554.
S. S. M Alqarni. A Review of Prevalence of Obesity in Saudi Arabia. J Obes Eat Disord. 2016;02(02). doi: 10.21767/2471-8203.100025.
Cutting the fat: More than 30,000 gastric sleeve surgeries in Saudi Arabia in 2020. Al Arabiya English. 14 Feb 2021. https://english.alarabiya.net/life-style/healthy-living/2021/02/14/Cutting-the-fat-More-than-30-000-gastric-sleeve-surgeries-in-Saudi-Arabia-in-2020 (accessed 26 Apr 2021).
T. A. Alwasaidi et al. Determining the prevalence and causes of anaemia in patients after bariatric surgery in a Saudi hospital. J Taibah Univ Med Sci. 2020;15(2):129–135. doi: 10.1016/j.jtumed.2020.02.001.
C. Gagnon, A. L. Schafer. Bone Health After Bariatric Surgery. JBMR Plus. 2018;2(3):121–133. doi: 10.1002/jbm4.10048.
E. W. Gregg, J. E. Shaw. Global Health Effects of Overweight and Obesity. N Engl J Med. 2017;377(1):80–81. doi: 10.1056/nejme1706095.
J. Bentham et al. Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults. Lancet. 2017;390(10113):2627–2642. doi: 10.1016/S0140-6736(17)32129-3.
R. W. Alberca et al. Obesity as a risk factor for COVID-19: an overview. Crit Rev Food Sci Nutr. 2020;0(0):1–15. doi: 10.1080/10408398.2020.1775546.
A. Hussain et al. Obesity and mortality of COVID-19. Meta-analysis. Obes Res Clin Pract. 2020;14(4):295–300. doi: 10.1016/j.orcp.2020.07.002.
M. Tremmel et al. Economic burden of obesity: A systematic literature review. Int J Environ Res Public Health. 2017;14(4):1–18. doi: 10.3390/ijerph14040435.
L. Angrisani et al. Bariatric Surgery Worldwide 2013. Obes Surg. 2015;25(10):1822–1832. doi: 10.1007/s11695-015-1657-z.
A. Guirat et al. What is the role of the sleeve gastrectomy in the surgical treatment of morbid obesity? Eur Surg - Acta Chir Austriaca. 2014;46(5):181–188. doi: 10.1007/s10353-014-0285-5.
J. Nudel, V. M. Sanchez. Surgical management of obesity. Metabolism. 2019;92:206–216. doi: 10.1016/j.metabol.2018.12.002.
S. Karmali et al. Bariatric surgery: A primer. Can Fam Physician. 2010;56(9):873–879.
G. Sanders, A. N. Kingsnorth. Gallstones. Br Med J. 2007;335(7614):295–299. doi: 10.1136/bmj.39267.452257.AD.
D. J. Scott et al. Intraoperative ultrasound and prophylactic ursodiol for gallstone prevention following laparoscopic gastric bypass. Surg Endosc Other Interv Tech. 2003;17(11):1796–1802. doi: 10.1007/s00464-002-8930-7.
A. E. Elshaer et al. Assessment of gallstones formation after bariatric surgery. Int Surg J. 2018;6(1):37. doi: 10.18203/2349-2902.isj20185120.
M. M. Brzozowska et al. Bariatric surgery, bone loss, obesity and possible mechanisms. Obes Rev. 2013;14(1):52–67. doi: 10.1111/j.1467-789X.2012.01050.x.
A. L. Schafer et al. Intestinal Calcium Absorption Decreases Dramatically after Gastric Bypass Surgery Despite Optimization of Vitamin D Status. J Bone Miner Res. 2015;30(8):1377–1385. doi: 10.1002/jbmr.2467.
Z. Tian et al. Changes in Bone Metabolism After Sleeve Gastrectomy Versus Gastric Bypass: a Meta-Analysis. Obes Surg. 2020;30(1):77–86. doi: 10.1007/s11695-019-04119-5.
S. Pellitero et al. Evaluation of Vitamin and Trace Element Requirements after Sleeve Gastrectomy at Long Term. Obes Surg. 2017;27(7):1674–1682. doi: 10.1007/s11695-017-2557-1.
N. Polruang et al. Prevalence and incidence of iron deficiency in patients undergoing bariatric surgery: A teaching hospital experience in Thailand. J Med Assoc Thail. 2020;103(2):115–120.
O. Jamil et al. Micronutrient deficiencies in laparoscopic sleeve gastrectomy. Nutrients. 2020;12(9):1–12. doi: 10.3390/nu12092896.
C. S. Arhi et al. The Complex Association Between Bariatric Surgery and Depression: a National Nested-Control Study. Obes Surg. 2021. doi: 10.1007/s11695-020-05201-z.
S. Alsubaie et al. Depression and anxiety on post-bariatric surgery among Saudi Adults residing in Abha, Asir Province, Saudi Arabia. Int J Med Dev Ctries. 2021;5(November 2020):165–171. doi: 10.24911/ijmdc.51-1605799192.
E. Esnafoglu, D. D. Ozturan. The relationship of severity of depression with homocysteine, folate, vitamin B12, and vitamin D levels in children and adolescents. Child Adolesc Ment Health. 2020;25(4):249–255. doi: 10.1111/camh.12387.
V. Menon et al. Vitamin D and Depression: A Critical Appraisal of the Evidence and Future Directions. Indian J Psychol Med. 2020;42(1):11–21. doi: 10.4103/IJPSYM.IJPSYM_160_19.
S. Ledoux et al. What Are the Micronutrient Deficiencies Responsible for the Most Common Nutritional Symptoms After Bariatric Surgery? Obes Surg. 2020;30(5):1891–1897. doi: 10.1007/s11695-020-04412-8.
A. Ukleja. Dumping Syndrome: pathophysiology and treatment. Nutr Clin Pract. 2005;20(5):517–525. doi: 10.1177/0115426505020005517.
A. Poljo et al. Incidence of Dumping Syndrome after Sleeve Gastrectomy, Roux-en-Y Gastric Bypass and One-Anastomosis Gastric Bypass. pp. 1–13.
D. Spirou, J. Raman, E. Smith. Psychological outcomes following surgical and endoscopic bariatric procedures: A systematic review. Obes Rev. 2020;21(6):1–24. doi: 10.1111/obr.12998.
S. Ledoux, M. Flamant, D. Calabrese, C. Bogard, O. Sami, and M. Coupaye, “What Are the Micronutrient Deficiencies Responsible for the Most Common Nutritional Symptoms After Bariatric Surgery?,” Obes. Surg., vol. 30, no. 5, pp. 1891–1897, 2020, doi: 10.1007/s11695-020-04412-8.