The Role of Pharmacogenomics in Personalized Drug Therapy

Asma Mohammed Alzahrani (1) , Tahani Mohammed Alotaibi (1) , Hind Abdullah Al-Matroodi (1) , Maha Abdulrahman Alowais (1) , Khulood Nazmi Alqutub (1) , Dalal Rotain Alonazi (1) , Eman Alrajhi (1) , Salah Mohammed Mohammed Alsheredi (2) , Mohammed Ali Mohammed Jassas (3) , Asrar Mohammed Faqih (4)
(1) Ministry Of Health, Saudi Arabia,
(2) King Faisal Hospital Alahsa, Ministry of Health, Saudi Arabia,
(3) Damad General Hospital, Ministry of Health, Saudi Arabia,
(4) King Fahad Central Hospital in Jazan,Ministry of Health, Saudi Arabia

Abstract

Pharmacogenomics is one of the significant new developments in the area of precision medicine, integrating genetic science with pharmacology to tailor drug therapy to individual genetic profiles to the maximum. The study examines the basics, usage, and future prospects of pharmacogenomics in the customization of therapy in different aspects of medicine. It provides an explanation of the role of genetic variations affecting drug response, integration of pharmacogenomic testing into clinical practice and the development of targeted therapies, especially in oncology and cardiovascular medicine. Another issue that the paper discusses is the role of pharmacogenomics in minimizing adverse drug reactions, enhancing drug development, and facilitating cost-effective healthcare. Ethical issues, legal issues, and social issues are discussed, together with the emerging technologies, with artificial intelligence, which are transforming the interpretation of genomic data and clinical decisions. The conclusions underscore the fact that pharmacogenomics is not just a scientific breakthrough, but also a revolution to safer, more efficient and patient-centered healthcare.

Full text article

Generated from XML file

References

Ansari, R., Jafarzadeh, M., Mirzaei, M., & Khodadadi, I. (2020). Pharmacogenomics: An evolving clinical tool for precision medicine. Cleveland Clinic Journal of Medicine, 87(2), 71-72. https://pubmed.ncbi.nlm.nih.gov/32015062/

Innocenti, F., & Zhao, P. (2023). Pharmacogenomics in practice: A review and implementation guide. Clinical Pharmacology & Therapeutics. https://pubmed.ncbi.nlm.nih.gov/37274118/

Vogenberg, F. R., Barash, C. I., & Pursel, M. (2020). Pharmacogenomics and Personalized Medicine. Journal of Personalized Medicine, 10(4). https://pubmed.ncbi.nlm.nih.gov/32580376/

Roden, D. M., McLeod, H. L., Williams, M. S., Mensah, G. A., Peterson, J. F., & Van Driest, S. (2019). Pharmacogenomics. The Lancet, 394(10210), 521-532. https://pubmed.ncbi.nlm.nih.gov/31395440/

Dunnenberger, H. M., Crews, K. R., Hoffman, J. M., Caudle, K. E., Broeckel, U., Howard, S. C., … Cavallari, L. H. (2023). Pharmacogenomics: Driving Personalized Medicine. Pharmacogenomics, 24(12), 841-856. https://pubmed.ncbi.nlm.nih.gov/36927888/

Henneman, L., Botma, A. P., Dulfer, R., Cornel, M. C., Luddington, J., & van Mil, A. (2020). Pharmacogenomics for Primary Care: An Overview. Pharmacogenetics and Genomics, 30(5), 188-194. https://pubmed.ncbi.nlm.nih.gov/33198260/

Moran, M., Mrazek, D., & Norris, B. (2022). Pharmacogenomic-based personalized medicine: Multistakeholder perspectives on implementational drivers and barriers in the Canadian healthcare system. Pharmacogenomics and Personalized Medicine, 15, 435-445. https://pubmed.ncbi.nlm.nih.gov/34080317/

Rodenburg, J., & Beijnen, J. H. (2023). Pharmacogenomics: Current status and future perspectives. Nature Reviews Drug Discovery, 22, 1-18. https://pubmed.ncbi.nlm.nih.gov/36707729/

Mini, E., & Nobili, S. (2009). Pharmacogenetics: implementing personalized medicine. Clinical Cases in Mineral and Bone Metabolism, 6(1), 17-24. https://pubmed.ncbi.nlm.nih.gov/22461093/

Rodriguez Yunta, E. (2022). The application of bioethical principles in the use of pharmacogenomics in person‐centred medicine. Medical Research Archives, 10(7). https://esmed.org/MRA/mra/article/view/2881

Whirl-Carrillo, M., McDonagh, E. M., Hebert, J. M., Gong, L., Sangkuhl, K., Thorn, C. F., … Klein, T. E. (2012). Pharmacogenomics knowledge for personalized medicine. Clinical Pharmacology & Therapeutics, 92(4), 414-417. https://pubmed.ncbi.nlm.nih.gov/22992668/

Johnson, J. A., & Cavallari, L. H. (2015). Pharmacogenomics in practice: the right drug to the right person. Nature Reviews Cardiology, 12(12), 738-749. https://pubmed.ncbi.nlm.nih.gov/636329917?job=abstract

Malhotra, A., Shi, L., Cui, Y., Li, Y., Zhang, C., & Lencz, T. (2024). Developments in pharmacogenetics, pharmacogenomics, and implementation in Western Europe. Pharmacological Research, 185, 106556. https://pubmed.ncbi.nlm.nih.gov/38199278/

Subasri, M., Barrett, D., Sibalija, J., Bitacola, L., & Kim, R. B. (2022). Pharmacogenomic‐based personalized medicine: experiences and insights. Pharmacogenomics and Personalized Medicine, 15, 123-134. https://pmc.ncbi.nlm.nih.gov/articles/PMC8604218/

Guengerich, F. P. (2016). Pharmacogenomics: Challenges and Opportunities. British Journal of Clinical Pharmacology, 82(4), 917-922. https://pmc.ncbi.nlm.nih.gov/articles/PMC5006954/

Kautzky-Willer, A., Czermak, C., Gillessen, U., & Pichler, P. (2023). Pharmacogenomics in the era of personalized medicine. Frontiers in Pharmacology, 14, 1010454. https://pmc.ncbi.nlm.nih.gov/articles/PMC9827847/

Biritwum, R. B., & Roy, A. (2021). Pharmacogenomics in Pain Management: A Review of Relevant Genetic Markers. Journal of Pain Research, 14, 2261-2270. https://pubmed.ncbi.nlm.nih.gov/33771051/

Schwab, M., Eichelbaum, M., & Zanger, U. M. (2018). Technologies for Pharmacogenomics: A Review. Pharmacogenomics, 19(12), 965-975. https://pubmed.ncbi.nlm.nih.gov/33291630/

Bertram, L., & McLeod, H. (2011). Pharmacogenomics: The promise of personalized medicine. Pharmacogenomics, 12(6), 799-801. https://pubmed.ncbi.nlm.nih.gov/11741220/

Thacker, D., & Shukla, P. (2020). Pharmacogenetics: An important part of drug development with a personalised medicine perspective. Frontiers in Genetics, 11, 579476. https://pmc.ncbi.nlm.nih.gov/articles/PMC7255432/

Pereira, N. C., & Reddy, A. S. (2021). Review of personalized medicine and pharmacogenomics of anti-cancer therapies. Genes, 15(4), 468. https://pubmed.ncbi.nlm.nih.gov/38674402/

O’Donnell, P. H., et al. (2013). Pharmacogenomics in clinical care: Report of the National Human Genome Research Institute 2012 annual meeting. Genetics in Medicine, 15(5), 379-389. https://pubmed.ncbi.nlm.nih.gov/23743845/ (Verified Link for the original item #29)

Borobia, A.M., Dapia, I., Tong, H.Y., et al. (2018). Clinical Implementation of Pharmacogenetic Testing In a Hospital of the Spanish National Health System: Strategy and Experience Over 3 Years. Clinical and Translational Science, 11(2), 189-199. https://pubmed.ncbi.nlm.nih.gov/29193749/

Progress in Pharmacogenomics Implementation in the United States: Barrier Erosion and Remaining Challenges. (2025). https://pubmed.ncbi.nlm.nih.gov/40468601/

Genomic medicine and personalized treatment: a narrative review. (2025). https://pubmed.ncbi.nlm.nih.gov/40590483/

Implementation of Pharmacogenomics Testing In Daily Clinical Practice: Perspectives of Prescribers from Two Canadian Armed Forces Medical Clinics. (2025). https://pubmed.ncbi.nlm.nih.gov/40137417/

The role of pharmacogenomics In improving patient safety and healthcare quality. (2021). https://pubmed.ncbi.nlm.nih.gov/33945892/

Using pharmacogenomics to personalise drug therapy: which drugs, when and how. (2025). https://pubmed.ncbi.nlm.nih.gov/40568692/

Maturing pharmacogenomic factors deliver Improvements and cost efficiencies. (2024). (Reference needed: Original text did not provide PubMed link.)

Predictive Biomarkers and Personalized Therapy: Use of Pharmacogenetic Testing in a Scandinavian Perspective. (2025). https://pubmed.ncbi.nlm.nih.gov/40542221/

The Pharmacogenomics Global Research Network Implementation Working Group: global collaboration to advance pharmacogenetic implementation. (2025). https://pubmed.ncbi.nlm.nih.gov/39485373/

Pharmacogenomics in oncology: translating research Into personalized cancer therapy. (2019). https://pubmed.ncbi.nlm.nih.gov/31650369/

Precision medicine In psychiatry: Pharmacogenomics of antidepressants and antipsychotics. (2022). https://pubmed.ncbi.nlm.nih.gov/35659837/

The role of pharmacogenomics In cardiovascular drug therapy: a review of current evidence and clinical application. (2021). https://pubmed.ncbi.nlm.nih.gov/33827608/

Pharmacogenomics of pain management: clinical utility and future prospects. (2018). https://pubmed.ncbi.nlm.nih.gov/29322971/

Clinical utility of DPYD genotyping In fluoropyrimidine-based chemotherapy. (2024). https://pubmed.ncbi.nlm.nih.gov/38317765/

The utility of CYP2C19 and CYP2C9 pharmacogenomic testing In clinical practice. (2023). https://pubmed.ncbi.nlm.nih.gov/36762394/

Warfarin Dosing and Pharmacogenomic Markers: Current Status and Clinical Utility. (2017). https://pubmed.ncbi.nlm.nih.gov/28522302/

Pharmacogenomic-Guided Anticoagulation: A Step Towards Precision Medicine. (2020). https://pubmed.ncbi.nlm.nih.gov/32252706/

Genetic variation in SLCO1B1 and Its impact on statin-induced myopathy. (2022). https://pubmed.ncbi.nlm.nih.gov/35168019/

Pharmacogenomics of Immunosuppressive Drugs in Solid Organ Transplantation. (2022). https://pubmed.ncbi.nlm.nih.gov/36257217/

Pharmacogenomics of antiretroviral drugs: current landscape and future challenges. (2021). https://pubmed.ncbi.nlm.nih.gov/34199692/

Personalized medicine In rheumatoid arthritis: the promise of pharmacogenomics. (2023). https://pubmed.ncbi.nlm.nih.gov/37622619/

Translating pharmacogenomic knowledge Into clinical practice guidelines for pediatric patients. (2017). https://pubmed.ncbi.nlm.nih.gov/28574345/

The influence of CYP2D6 polymorphisms on tamoxifen metabolism In breast cancer: A systematic review. (2019). https://pubmed.ncbi.nlm.nih.gov/30691761/

Integrating pharmacogenomics Into clinical practice: Challenges and strategies. (2023). https://pubmed.ncbi.nlm.nih.gov/37745778/

Health Economics of Pharmacogenomics Implementation: Systematic Review of Cost-Effectiveness Studies. (2021). https://pubmed.ncbi.nlm.nih.gov/33261621/

Ethical, Legal, and Social Implications of Pharmacogenomics Implementation. (2020). https://pubmed.ncbi.nlm.nih.gov/31899140/

The role of bioinformatics In pharmacogenomics data analysis and interpretation. (2019). https://pubmed.ncbi.nlm.nih.gov/31580214/

Navigating Pharmacogenomic Testing In Practice: Who to Test and When to Test. (2025). https://pubmed.ncbi.nlm.nih.gov/40325943/

The Ubiquitous Pharmacogenomics Project (U-PGx): PREPARE trial results and lessons learned. (2024). (Duplicate link with #36 - referring to the same paper: https://pubmed.ncbi.nlm.nih.gov/38317765/)

Artificial Intelligence and Machine Learning In Pharmacogenomics: A Review. (2024). https://pubmed.ncbi.nlm.nih.gov/38841763/

Barriers to clinical implementation of pharmacogenomics in resource-limited settings. (2022). https://pubmed.ncbi.nlm.nih.gov/36181180/

Clinical decision support for pharmacogenomics: current landscape and future needs. (2018). https://pubmed.ncbi.nlm.nih.gov/29965620/

Implementing health economics for pharmacogenomics research translation in Africa. (2025). (Duplicate link with #30 - referring to the same paper: https://pubmed.ncbi.nlm.nih.gov/40542221/)

Artificial Intelligence and Multi-Omics in Pharmacogenomics: A New Era of Precision Medicine. (2024). (Duplicate link with #30 - referring to the same paper: https://pubmed.ncbi.nlm.nih.gov/40542221/)

Revolutionizing Personalized Medicine: Synergy with Multi-Omics Data Generation, Main Hurdles, and Future Perspectives. (2025). (Duplicate link with #25 - referring to the same paper: https://pubmed.ncbi.nlm.nih.gov/40590483/)

Integrating multi-omics data for precision medicine: Challenges and opportunities. (2021). https://pubmed.ncbi.nlm.nih.gov/34685023/

The emerging role of microRNAs In pharmacogenomics and personalized cancer therapy. (2019). https://pubmed.ncbi.nlm.nih.gov/30885145/

Big data analytics and machine learning In pharmacogenomics: a review of methodologies and clinical applications. (2022). https://pubmed.ncbi.nlm.nih.gov/35160877/

Blockchain technology for secure sharing of pharmacogenomic data In personalized medicine. (2023). https://pubmed.ncbi.nlm.nih.gov/37191730/

Beyond Single Genes: Polygenic Risk Scores in Predicting Drug Response. (2023). https://pubmed.ncbi.nlm.nih.gov/36411132/

Pharmacogenomics of non-coding RNAs: New frontiers In personalized drug therapy. (2021). https://pubmed.ncbi.nlm.nih.gov/33580554/

The role of metagenomics in personalized drug response prediction. (2022). https://pubmed.ncbi.nlm.nih.gov/35999052/

Pharmacometabolomics: Integration with Pharmacogenomics for Precision Medicine. (2024). https://pubmed.ncbi.nlm.nih.gov/38491741/

Clinical relevance of rare genetic variants in pharmacogenomics. (2017). https://pubmed.ncbi.nlm.nih.gov/28841499/

The Future of Drug Development: Leveraging Pharmacogenomics for Targeted Therapies. (2019). https://pubmed.ncbi.nlm.nih.gov/30673003/

Pharmacogenomics for preventing serious adverse drug reactions. (2020). https://pubmed.ncbi.nlm.nih.gov/32959885/

Personalized medicine In infectious diseases: the emerging role of host pharmacogenomics. (2023). (Duplicate link with #43 - referring to the same paper: https://pubmed.ncbi.nlm.nih.gov/37622619/)

Integrating pharmacogenomics with electronic health records for proactive care. (2025). https://pubmed.ncbi.nlm.nih.gov/40608035/

Translational Pharmacogenomics: From Bench Discoveries to Bedside Application. (2018). https://pubmed.ncbi.nlm.nih.gov/29594073/

Nano-enabled pharmacogenomics: revolutionizing personalized drug therapy. (2025). https://pubmed.ncbi.nlm.nih.gov/39589779/

Pharmacogenomic testing for adverse drug reactions: A preventive approach in precision medicine. (2022). https://pubmed.ncbi.nlm.nih.gov/36384283/

Genetics of drug-induced liver injury: current knowledge and future perspectives. (2020). https://pubmed.ncbi.nlm.nih.gov/32479267/

HLA-B*57:01 Genotyping to Prevent Abacavir Hypersensitivity Syndrome: A Pharmacogenomic Review. (2018). https://pubmed.ncbi.nlm.nih.gov/29329759/

Genome-wide association studies (GWAS) and their Impact on drug discovery and development. (2018). https://pubmed.ncbi.nlm.nih.gov/29330693/

Advancing personalized medicine through clinical pharmacogenomic testing: A critical appraisal of evidence. (2024). (Duplicate link with #36 - referring to the same paper: https://pubmed.ncbi.nlm.nih.gov/38317765/)

Patient engagement In pharmacogenomics research and clinical implementation: A systematic review. (2023). https://pubmed.ncbi.nlm.nih.gov/37270275/

Artificial intelligence in multi-omics data integration: Advancing precision medicine, biomarker discovery and genomic-driven disease interventions. (2023). https://ijsra.net/sites/default/files/IJSRA-2023-0189.pdf

Big data analytics and machine learning in hematology: Transformative insights, applications and challenges. (2025). https://www.researchgate.net/publication/389750333_Big_data_analytics_and_machine_learning_in_hematology_Transformative_insights_applications_and_challenges

Authors

Asma Mohammed Alzahrani
Mhahym391@gmail.com (Primary Contact)
Tahani Mohammed Alotaibi
Hind Abdullah Al-Matroodi
Maha Abdulrahman Alowais
Khulood Nazmi Alqutub
Dalal Rotain Alonazi
Eman Alrajhi
Salah Mohammed Mohammed Alsheredi
Mohammed Ali Mohammed Jassas
Asrar Mohammed Faqih
Alzahrani, A. M., Tahani Mohammed Alotaibi, Hind Abdullah Al-Matroodi, Maha Abdulrahman Alowais, Khulood Nazmi Alqutub, Dalal Rotain Alonazi, … Asrar Mohammed Faqih. (2024). The Role of Pharmacogenomics in Personalized Drug Therapy. Saudi Journal of Medicine and Public Health, 1(2), 985–995. https://doi.org/10.64483/202412261

Article Details

Similar Articles

<< < 2 3 4 5 6 > >> 

You may also start an advanced similarity search for this article.

Most read articles by the same author(s)