Interdisciplinary Clinical Management and Nursing Care Approaches in Scarlet Fever

Ghadeer Saleh Alsaqer (1) , Abdullah Ali Mufadhi Alharbi (2) , Basmah Hamad Khardali (3) , Faten Meawadh Talaq Almutairi  (4) , Malak Qasem Habib Mutyi (5) , Noah Abduallh Alanazi (6) , Bador Shaiem M Remal (7) , Dikheel Ali Dikheel Alshammary (3) , Alawiaa Abdalmjid Alali  (3) , Mubarak Barak Alosaimi (8) , Abdulmajeed Abdullah Alanazi (9) , Nawaf Mohmmed Saad Alsehli (10)
(1) Aljouf Health Cluster, Ministry of Health, Saudi Arabia,
(2) Aldar Albaidaa First Health Center Riyadh , Ministry of Health, Saudi Arabia,
(3) Ministry Of Health, Saudi Arabia,
(4) Althibiah Primary Health Care, Ministry of Health, Saudi Arabia,
(5) Al-Iman Hospital Riyadh, Ministry of Health, Saudi Arabia,
(6) Al-Nasifah Health Center In Al-Kharj, Ministry of Health, Saudi Arabia,
(7) Al-Jouf Health Cluster Al-Radifa Health Center Dumat Al-Jandal, Ministry of Health, Saudi Arabia,
(8) Dawadmi General Hospital, Ministry of Health, Saudi Arabia,
(9) Eradah Hospital And Mental Health Al-Kharj, Ministry of Health, Saudi Arabia,
(10) Women's, Maternity And Children's Hospital In Medina, Ministry of Health, Saudi Arabia

Abstract

Background: Scarlet fever is an acute, toxin-mediated illness caused by Group A Streptococcus pyogenes (GAS), historically a major cause of childhood morbidity and mortality. It is characterized by a distinctive sandpaper-like rash, strawberry tongue, and fever, primarily affecting school-aged children. The disease has seen a global resurgence in recent decades, linked to the emergence of more virulent GAS strains.


Aim: This article aims to provide a comprehensive overview of scarlet fever, detailing its etiology, pathophysiology, clinical presentation, and the critical importance of timely diagnosis and management to prevent both acute suppurative complications and severe immune-mediated sequelae like acute rheumatic fever and poststreptococcal glomerulonephritis.


Methods: The diagnosis is primarily clinical, based on characteristic signs and symptoms, and confirmed through laboratory testing such as rapid antigen detection tests (RADT) and throat culture. Molecular methods like PCR are increasingly used for strain identification during outbreaks. Management centers on antibiotic therapy and supportive care.


Results: Penicillin remains the first-line antibiotic treatment, effectively reducing symptom duration, transmission, and complication risks. However, rising macrolide and clindamycin resistance in some regions complicates management for penicillin-allergic patients. With prompt treatment, the prognosis is excellent, though complications can arise from delayed or inadequate care.


Conclusion: Scarlet fever is a re-emerging public health concern. Its successful management relies on a coordinated, interprofessional approach involving clinicians, nurses, and pharmacists for accurate diagnosis, appropriate treatment, patient education, and infection control to optimize individual and community health outcomes.

Full text article

Generated from XML file

References

Walker MJ, Brouwer S. Scarlet fever makes a comeback. Lancet Infect Dis. 2018 Feb;18(2):128-129.

Gera K, McIver KS. Laboratory growth and maintenance of Streptococcus pyogenes (the Group A Streptococcus, GAS). Curr Protoc Microbiol. 2013 Oct 02;30:9D.2.1-9D.2.13.

Cordery R, Purba AK, Begum L, Mills E, Mosavie M, Vieira A, Jauneikaite E, Leung RCY, Siggins MK, Ready D, Hoffman P, Lamagni T, Sriskandan S. Frequency of transmission, asymptomatic shedding, and airborne spread of Streptococcus pyogenes in schoolchildren exposed to scarlet fever: a prospective, longitudinal, multicohort, molecular epidemiological, contact-tracing study in England, UK. Lancet Microbe. 2022 May;3(5):e366-e375.

Lamagni TL, Darenberg J, Luca-Harari B, Siljander T, Efstratiou A, Henriques-Normark B, Vuopio-Varkila J, Bouvet A, Creti R, Ekelund K, Koliou M, Reinert RR, Stathi A, Strakova L, Ungureanu V, Schalén C, Strep-EURO Study Group. Jasir A. Epidemiology of severe Streptococcus pyogenes disease in Europe. J Clin Microbiol. 2008 Jul;46(7):2359-67

Shannon BA, McCormick JK, Schlievert PM. Toxins and Superantigens of Group A Streptococci. Microbiol Spectr. 2019 Jan;7(1)

Brouwer S, Rivera-Hernandez T, Curren BF, Harbison-Price N, De Oliveira DMP, Jespersen MG, Davies MR, Walker MJ. Pathogenesis, epidemiology and control of Group A Streptococcus infection. Nat Rev Microbiol. 2023 Jul;21(7):431-447.

Katz AR, Morens DM. Severe streptococcal infections in historical perspective. Clin Infect Dis. 1992 Jan;14(1):298-307.

Barnett TC, Bowen AC, Carapetis JR. The fall and rise of Group A Streptococcus diseases. Epidemiol Infect. 2018 Aug 15;147:e4.

Dunne EM, Hutton S, Peterson E, Blackstock AJ, Hahn CG, Turner K, Carter KK. Increasing Incidence of Invasive Group A Streptococcus Disease, Idaho, USA, 2008-2019. Emerg Infect Dis. 2022 Sep;28(9):1785-1795.

de Loizaga SR, Beaton AZ. Rheumatic Fever and Rheumatic Heart Disease in the United States. Pediatr Ann. 2021 Mar;50(3):e98-e104.

Gherardi G, Vitali LA, Creti R. Prevalent emm Types among Invasive GAS in Europe and North America since Year 2000. Front Public Health. 2018;6:59.

van Sorge NM, Cole JN, Kuipers K, Henningham A, Aziz RK, Kasirer-Friede A, Lin L, Berends ETM, Davies MR, Dougan G, Zhang F, Dahesh S, Shaw L, Gin J, Cunningham M, Merriman JA, Hütter J, Lepenies B, Rooijakkers SHM, Malley R, Walker MJ, Shattil SJ, Schlievert PM, Choudhury B, Nizet V. The classical lancefield antigen of group a Streptococcus is a virulence determinant with implications for vaccine design. Cell Host Microbe. 2014 Jun 11;15(6):729-740.

Lancefield Rc. The Antigenic Complex Of Streptococcus Haemolyticus : I. Demonstration Of A Type-Specific Substance In Extracts Of Streptococcus Haemolyticus. J Exp Med. 1928 Jan 01;47(1):91-103.

Raabe VN, Shane AL. Group B Streptococcus (Streptococcus agalactiae). Microbiol Spectr. 2019 Mar;7(2)

Walker MJ, Barnett TC, McArthur JD, Cole JN, Gillen CM, Henningham A, Sriprakash KS, Sanderson-Smith ML, Nizet V. Disease manifestations and pathogenic mechanisms of Group A Streptococcus. Clin Microbiol Rev. 2014 Apr;27(2):264-301.

Atchade E, De Tymowski C, Grall N, Tanaka S, Montravers P. Toxic Shock Syndrome: A Literature Review. Antibiotics (Basel). 2024 Jan 18;13(1)

Sanderson-Smith M, De Oliveira DM, Guglielmini J, McMillan DJ, Vu T, Holien JK, Henningham A, Steer AC, Bessen DE, Dale JB, Curtis N, Beall BW, Walker MJ, Parker MW, Carapetis JR, Van Melderen L, Sriprakash KS, Smeesters PR., M Protein Study Group. A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development. J Infect Dis. 2014 Oct 15;210(8):1325-38.

Tagini F, Aubert B, Troillet N, Pillonel T, Praz G, Crisinel PA, Prod'hom G, Asner S, Greub G. Importance of whole genome sequencing for the assessment of outbreaks in diagnostic laboratories: analysis of a case series of invasive Streptococcus pyogenes infections. Eur J Clin Microbiol Infect Dis. 2017 Jul;36(7):1173-1180.

Rodriguez-Ruiz JP, Lin Q, Lammens C, Smeesters PR, van Kleef-van Koeveringe S, Matheeussen V, Malhotra-Kumar S. Increase in bloodstream infections caused by emm1 group A Streptococcus correlates with emergence of toxigenic M1UK, Belgium, May 2022 to August 2023. Euro Surveill. 2023 Sep;28(36)

Wong SSY, Yuen KY. The Comeback of Scarlet Fever. EBioMedicine. 2018 Feb;28:7-8.

You Y, Davies MR, Protani M, McIntyre L, Walker MJ, Zhang J. Scarlet Fever Epidemic in China Caused by Streptococcus pyogenes Serotype M12: Epidemiologic and Molecular Analysis. EBioMedicine. 2018 Feb;28:128-135.

Wong SS, Yuen KY. Streptococcus pyogenes and re-emergence of scarlet fever as a public health problem. Emerg Microbes Infect. 2012 Jul;1(7):e2.

Avire NJ, Whiley H, Ross K. A Review of Streptococcus pyogenes: Public Health Risk Factors, Prevention and Control. Pathogens. 2021 Feb 22;10(2)

Thompson KM, Sterkel AK, McBride JA, Corliss RF. The Shock of Strep: Rapid Deaths Due to Group a Streptococcus. Acad Forensic Pathol. 2018 Mar;8(1):136-149.

Stevens DL, Bryant AE. Streptococcus pyogenes Impetigo, Erysipelas, and Cellulitis. In: Ferretti JJ, Stevens DL, Fischetti VA, editors. Streptococcus pyogenes: Basic Biology to Clinical Manifestations [Internet]. 2nd ed. University of Oklahoma Health Sciences Center; Oklahoma City (OK): Sep 7, 2022.

Martin JM, Green M. Group A streptococcus. Semin Pediatr Infect Dis. 2006 Jul;17(3):140-8.

Shulman ST, Bisno AL, Clegg HW, Gerber MA, Kaplan EL, Lee G, Martin JM, Van Beneden C., Infectious Diseases Society of America. Clinical practice guideline for the diagnosis and management of group A streptococcal pharyngitis: 2012 update by the Infectious Diseases Society of America. Clin Infect Dis. 2012 Nov 15;55(10):e86-102.

Oliver J, Malliya Wadu E, Pierse N, Moreland NJ, Williamson DA, Baker MG. Group A Streptococcus pharyngitis and pharyngeal carriage: A meta-analysis. PLoS Negl Trop Dis. 2018 Mar;12(3):e0006335.

Carville KS, Meagher N, Abo YN, Manski-Nankervis JA, Fielding J, Steer A, McVernon J, Price DJ. Burden of antimicrobial prescribing in primary care attributable to sore throat: a retrospective cohort study of patient record data. BMC Prim Care. 2024 Apr 17;25(1):117.

Nelson GE, Pondo T, Toews KA, Farley MM, Lindegren ML, Lynfield R, Aragon D, Zansky SM, Watt JP, Cieslak PR, Angeles K, Harrison LH, Petit S, Beall B, Van Beneden CA. Epidemiology of Invasive Group A Streptococcal Infections in the United States, 2005-2012. Clin Infect Dis. 2016 Aug 15;63(4):478-86.

Carapetis JR, Steer AC, Mulholland EK, Weber M. The global burden of group A streptococcal diseases. Lancet Infect Dis. 2005 Nov;5(11):685-94.

Vieira A, Wan Y, Ryan Y, Li HK, Guy RL, Papangeli M, Huse KK, Reeves LC, Soo VWC, Daniel R, Harley A, Broughton K, Dhami C, Ganner M, Ganner MA, Mumin Z, Razaei M, Rundberg E, Mammadov R, Mills EA, Sgro V, Mok KY, Didelot X, Croucher NJ, Jauneikaite E, Lamagni T, Brown CS, Coelho J, Sriskandan S. Rapid expansion and international spread of M1UK in the post-pandemic UK upsurge of Streptococcus pyogenes. Nat Commun. 2024 May 10;15(1):3916.

Nasser W, Beres SB, Olsen RJ, Dean MA, Rice KA, Long SW, Kristinsson KG, Gottfredsson M, Vuopio J, Raisanen K, Caugant DA, Steinbakk M, Low DE, McGeer A, Darenberg J, Henriques-Normark B, Van Beneden CA, Hoffmann S, Musser JM. Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences. Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):E1768-76.

Zhi X, Li HK, Li H, Loboda Z, Charles S, Vieira A, Huse K, Jauneikaite E, Reeves L, Mok KY, Coelho J, Lamagni T, Sriskandan S. Emerging Invasive Group A Streptococcus M1UK Lineage Detected by Allele-Specific PCR, England, 20201. Emerg Infect Dis. 2023 May;29(5):1007-1010.

Luca-Harari B, Darenberg J, Neal S, Siljander T, Strakova L, Tanna A, Creti R, Ekelund K, Koliou M, Tassios PT, van der Linden M, Straut M, Vuopio-Varkila J, Bouvet A, Efstratiou A, Schalén C, Henriques-Normark B, Strep-EURO Study Group. Jasir A. Clinical and microbiological characteristics of severe Streptococcus pyogenes disease in Europe. J Clin Microbiol. 2009 Apr;47(4):1155-65.

Lau EH, Nishiura H, Cowling BJ, Ip DK, Wu JT. Scarlet fever outbreak, Hong Kong, 2011. Emerg Infect Dis. 2012 Oct;18(10):1700-2.

Hsieh YC, Huang YC. Scarlet fever outbreak in Hong Kong, 2011. J Microbiol Immunol Infect. 2011 Dec;44(6):409-11.

Lamagni T, Guy R, Chand M, Henderson KL, Chalker V, Lewis J, Saliba V, Elliot AJ, Smith GE, Rushton S, Sheridan EA, Ramsay M, Johnson AP. Resurgence of scarlet fever in England, 2014-16: a population-based surveillance study. Lancet Infect Dis. 2018 Feb;18(2):180-187.

Lynskey NN, Jauneikaite E, Li HK, Zhi X, Turner CE, Mosavie M, Pearson M, Asai M, Lobkowicz L, Chow JY, Parkhill J, Lamagni T, Chalker VJ, Sriskandan S. Emergence of dominant toxigenic M1T1 Streptococcus pyogenes clone during increased scarlet fever activity in England: a population-based molecular epidemiological study. Lancet Infect Dis. 2019 Nov;19(11):1209-1218.

Li HK, Zhi X, Vieira A, Whitwell HJ, Schricker A, Jauneikaite E, Li H, Yosef A, Andrew I, Game L, Turner CE, Lamagni T, Coelho J, Sriskandan S. Characterization of emergent toxigenic M1UKStreptococcus pyogenes and associated sublineages. Microb Genom. 2023 Apr;9(4)

Hurst JR, Brouwer S, Walker MJ, McCormick JK. Streptococcal superantigens and the return of scarlet fever. PLoS Pathog. 2021 Dec;17(12):e1010097

Schlievert PM, Bettin KM, Watson DW. Reinterpretation of the Dick test: role of group A streptococcal pyrogenic exotoxin. Infect Immun. 1979 Nov;26(2):467-72.

Shulman ST, Bisno AL, Clegg HW, Gerber MA, Kaplan EL, Lee G, Martin JM, Van Beneden C. Clinical practice guideline for the diagnosis and management of group A streptococcal pharyngitis: 2012 update by the Infectious Diseases Society of America. Clin Infect Dis. 2012 Nov 15;55(10):1279-82.

Schroeder BM. Diagnosis and management of group A streptococcal pharyngitis. Am Fam Physician. 2003 Feb 15;67(4):880, 883-4.

Kanagasabai A, Evans C, Jones HE, Hay AD, Dawson S, Savović J, Elwenspoek MMC. Systematic review and meta-analysis of the accuracy of McIsaac and Centor score in patients presenting to secondary care with pharyngitis. Clin Microbiol Infect. 2024 Apr;30(4):445-452.

Basetti S, Hodgson J, Rawson TM, Majeed A. Scarlet fever: a guide for general practitioners. London J Prim Care (Abingdon). 2017 Sep;9(5):77-79.

Managing scarlet fever. Drug Ther Bull. 2017 Sep;55(9):102.

Chalker V, Jironkin A, Coelho J, Al-Shahib A, Platt S, Kapatai G, Daniel R, Dhami C, Laranjeira M, Chambers T, Guy R, Lamagni T, Harrison T, Chand M, Johnson AP, Underwood A., Scarlet Fever Incident Management Team. Genome analysis following a national increase in Scarlet Fever in England 2014. BMC Genomics. 2017 Mar 10;18(1):224.

Wessels MR. Pharyngitis and Scarlet Fever. In: Ferretti JJ, Stevens DL, Fischetti VA, editors. Streptococcus pyogenes: Basic Biology to Clinical Manifestations [Internet]. University of Oklahoma Health Sciences Center; Oklahoma City (OK): Feb 10, 2016.

Wang J, Zhou N, Xu B, Hao H, Kang L, Zheng Y, Jiang Y, Jiang H. Identification and cluster analysis of Streptococcus pyogenes by MALDI-TOF mass spectrometry. PLoS One. 2012;7(11):e47152.

Cohen JF, Bertille N, Cohen R, Chalumeau M. Rapid antigen detection test for group A streptococcus in children with pharyngitis. Cochrane Database Syst Rev. 2016 Jul 04;7(7):CD010502.

Liu D, Hollingshead S, Swiatlo E, Lawrence ML, Austin FW. Rapid identification of Streptococcus pyogenes with PCR primers from a putative transcriptional regulator gene. Res Microbiol. 2005 May;156(4):564-7.

Macris MH, Hartman N, Murray B, Klein RF, Roberts RB, Kaplan EL, Horn D, Zabriskie JB. Studies of the continuing susceptibility of group A streptococcal strains to penicillin during eight decades. Pediatr Infect Dis J. 1998 May;17(5):377-81.

Yu D, Zheng Y, Yang Y. Is There Emergence of β-Lactam Antibiotic-Resistant Streptococcus pyogenes in China? Infect Drug Resist. 2020;13:2323-2327.

Rafei R, Al Iaali R, Osman M, Dabboussi F, Hamze M. A global snapshot on the prevalent macrolide-resistant emm types of Group A Streptococcus worldwide, their phenotypes and their resistance marker genotypes during the last two decades: A systematic review. Infect Genet Evol. 2022 Apr;99:105258.

Gergova R, Boyanov V, Muhtarova A, Alexandrova A. A Review of the Impact of Streptococcal Infections and Antimicrobial Resistance on Human Health. Antibiotics (Basel). 2024 Apr 15;13(4)

Sun L, Xiao Y, Huang W, Lai J, Lyu J, Ye B, Chen H, Gu B. Prevalence and identification of antibiotic-resistant scarlet fever group A Streptococcus strains in some paediatric cases at Shenzhen, China. J Glob Antimicrob Resist. 2022 Sep;30:199-204.

Schmitz M, Roux X, Huttner B, Pugin J. Streptococcal toxic shock syndrome in the intensive care unit. Ann Intensive Care. 2018 Sep 17;8(1):88.

Johnson AF, LaRock CN. Antibiotic Treatment, Mechanisms for Failure, and Adjunctive Therapies for Infections by Group A Streptococcus. Front Microbiol. 2021;12:760255.

Stevens DL. Invasive group A streptococcal disease. Infect Agents Dis. 1996 Jun;5(3):157-66.

Stevens DL. Invasive group A streptococcus infections. Clin Infect Dis. 1992 Jan;14(1):2

Wang HC, Lau CI, Lin CC, Chang A, Kao CH. Group A Streptococcal Infections Are Associated With Increased Risk of Pediatric Neuropsychiatric Disorders: A Taiwanese Population-Based Cohort Study. J Clin Psychiatry. 2016 Jul;77(7):e848-54.

Yung CF, Thoon KC. A 12 year outbreak of scarlet fever in Singapore. Lancet Infect Dis. 2018 Sep;18(9):942

Salerno J. Pediatric management problems. What is your assessment? Scarlet fever. Pediatr Nurs. 1996 Mar-Apr;22(2):152-3.

Radikas R, Connolly C. Young patients in a young nation: scarlet fever in early nineteenth century rural New England. Pediatr Nurs. 2007 Jan-Feb;33(1):53-5.

Authors

Ghadeer Saleh Alsaqer
Galsaqer@Moh.Gov.Sa (Primary Contact)
Abdullah Ali Mufadhi Alharbi
Basmah Hamad Khardali
Faten Meawadh Talaq Almutairi 
Malak Qasem Habib Mutyi
Noah Abduallh Alanazi
Bador Shaiem M Remal
Dikheel Ali Dikheel Alshammary
Alawiaa Abdalmjid Alali 
Mubarak Barak Alosaimi
Abdulmajeed Abdullah Alanazi
Nawaf Mohmmed Saad Alsehli
Alsaqer, G. S., Abdullah Ali Mufadhi Alharbi, Basmah Hamad Khardali, Faten Meawadh Talaq Almutairi , Malak Qasem Habib Mutyi, Noah Abduallh Alanazi, … Nawaf Mohmmed Saad Alsehli. (2024). Interdisciplinary Clinical Management and Nursing Care Approaches in Scarlet Fever. Saudi Journal of Medicine and Public Health, 1(2), 902–917. https://doi.org/10.64483/202412246

Article Details

Similar Articles

<< < 3 4 5 

You may also start an advanced similarity search for this article.