The Prescription for Value and Efficiency: A Systematic Review of Artificial Intelligence in Optimizing Pharmacy Business and Drug Prices

Ahmed Ali Mussa Naji (1) , Rehab Moaied Abdo Bagal (1) , Ali Hassan Ibrahim Khormi , Abdulrahman Yahya Ahmed Masrai (2) , Asim Omar Mohammed Hakami , Ahmed Mohsen Mohammed Maswdi (3) , Mohammed Saleh Mohammed Sayed , Ahmed Hussain Ahmed Zalah , Mohammed Mohsen Abdu Khormi , Talal Qasim Mosa Mashragi (4) , Ibrahim Abu Bakr Hakami , Ahmad Nahari Mohammad Madkhali (5) , Abdullah Mohsen Mohammed Maswdi (6) , Ahmad Abdullah Ali Majrashi (4) , Mazen Qassem Buhais Ozaybi (7) , Radwan Yehya Salim Moudhah
(1) King Fahad Hospital in Jazan,Ministry of Health, Saudi Arabia,
(2) Gazan Health Cluster,Ministry of Health, Saudi Arabia,
(3) King Fahd Central Hospital in Jazan,Ministry of Health, Saudi Arabia,
(4) King Fahad Central Hospital in Jazan,Ministry of Health, Saudi Arabia,
(5) Medical Supply Jazan,Ministry of Health, Saudi Arabia,
(6) Abu Arish General Hospital in Jazan,Ministry of Health, Saudi Arabia,
(7) Alkhadrah Primary Health Care, Ministry of Health, Saudi Arabia

Abstract

Background: Healthcare is facing unprecedented stress due to the threat of rising costs, drug shortages, and inefficiency in operations. Pharmacy operations, starting from the manufacturing plant to the patient's bedside, and the complex nexus of drug prices are important areas crying out for disruption. Artificial intelligence (AI), specifically machine learning (ML), natural language processing (NLP), and robotic process automation (RPA), is being viewed increasingly as a game-changing force that can help counter these problems.


Aim: The aim of this systematic review is to integrate current literature and evidence on the application of AI for streamlining pharma operations and justifying drug cost.


Methods: We systematically searched peer-reviewed articles, reports, and clinical trials published between 2010 and 2025.


Results: The findings reflect that AI-based solutions are being used effectively across the value chain of pharma. In operations, AI systems streamline inventory management, automate dispensing, improve clinical decision support, and personalize medication adherence programs. In drug pricing, AI algorithms are transforming market access approaches, optimizing payer reimbursement contracts, and informing value-based pricing models using advanced analysis of real-world evidence (RWE). Although the potential is great, numerous challenges remain, including data privacy concerns, algorithmic bias, the "black box" issue, and regulatory challenges.


Conclusion: The review opines that AI is not only an incremental but also a paradigm change towards improved, safer, and value-based pharmacy practice. Strategic investment, cross-disciplinary convergence, and robust regulatory frameworks are essential to unlock the full potential of AI in creating an enduring and patient-centric pharmaceutical system.

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References

Gilson AM, Xiong KZ, Stone JA, Jacobson N, Phelan C, Reddy A, Chui MA. Improving patient-pharmacist encounters with over-the-counter medications: A mixed-methods pilot study. INNOVATIONS in pharmacy. 2020 Feb 14;11(1):10-24926. https://doi.org/10.24926/iip.v11i1.2295

Kesselheim AS, Avorn J, Sarpatwari A. The high cost of prescription drugs in the United States: origins and prospects for reform. Jama. 2016 Aug 23;316(8):858-71. doi:10.1001/jama.2016.11237

Alhabeeb S, Almetrek AA, Al-Amri MI, Alajlan AA, Alfehaid FA, Alsaudi MK, Alsheeb AA. Pharmacological Role and Clinical Applications of 5α-Reductase Inhibitors-Review Article for Pharmacists and Healthcare Professionals. Saudi Journal of Medicine and Public Health. 2025 Jul 18;2(2):85-94. https://doi.org/10.64483/jmph-40‬‬‬

Sutton RT, Pincock D, Baumgart DC, Sadowski DC, Fedorak RN, Kroeker KI. An overview of clinical decision support systems: benefits, risks, and strategies for success. NPJ digital medicine. 2020 Feb 6;3(1):17. https://doi.org/10.1038/s41746-020-0221-y

Zhu X, Ninh A, Zhao H, Liu Z. Demand forecasting with supply‐chain information and machine learning: Evidence in the pharmaceutical industry. Production and Operations Management. 2021 Sep;30(9):3231-52. https://doi.org/10.1111/poms.13426

Abu Zwaida T, Pham C, Beauregard Y. Optimization of inventory management to prevent drug shortages in the hospital supply chain. Applied Sciences. 2021 Mar 18;11(6):2726. https://doi.org/10.3390/app11062726

Pratyaksa H, Permanasari AE, Fauziati S, Fitriana I. Arima implementation to predict the amount of antiseptic medicine usage in veterinary hospital. In2016 1st international conference on biomedical engineering (ibiomed) 2016 Oct 5 (pp. 1-4). IEEE. doi: 10.1109/IBIOMED.2016.7869815.

Maashi, F. M. M., Alfaifi, A. M. J., Maeshi, Hatem M., Alfaifi, I. M. H., Maashi, A. M. M., Alfaifi, F. H., … Mashi, K. M. M. Personalized Approaches to Pharmacotherapy and Physiotherapy in Obstetric Treatment: Improving Medication Safety and Physical Wellness for Pregnant Women. Saudi Journal of Medicine and Public Health. 2025;2(2): 95–104. https://doi.org/10.64483/jmph-45‬‬‬

Van der Aalst WM, Bichler M, Heinzl A. Robotic process automation. Business & information systems engineering. 2018 Aug;60(4):269-72. https://doi.org/10.1007/s12599-018-0542-4

Kim S, Park EY, Kim JS, Ihm SY. Combination Pattern Method Using Deep Learning for Pill Classification. Applied Sciences. 2024 Oct 8;14(19):9065. https://doi.org/10.3390/app14199065

Baryannis G, Validi S, Dani S, Antoniou G. Supply chain risk management and artificial intelligence: state of the art and future research directions. International journal of production research. 2019 Apr 3;57(7):2179-202. https://doi.org/10.1080/00207543.2018.1530476

Wei Q, Ji Z, Li Z, Du J, Wang J, Xu J, Xiang Y, Tiryaki F, Wu S, Zhang Y, Tao C. A study of deep learning approaches for medication and adverse drug event extraction from clinical text. Journal of the American Medical Informatics Association. 2020 Jan;27(1):13-21. https://doi.org/10.1093/jamia/ocz063

Wong A, Rehr C, Seger DL, Amato MG, Beeler PE, Slight SP, Wright A, Bates DW. Evaluation of harm associated with high dose-range clinical decision support overrides in the intensive care unit. Drug safety. 2019 Apr 5;42(4):573-9. https://doi.org/10.1007/s40264-018-0756-x

Lv H, Yang X, Wang B, Wang S, Du X, Tan Q, Hao Z, Liu Y, Yan J, Xia Y. Machine learning–driven models to predict prognostic outcomes in patients hospitalized with heart failure using electronic health records: Retrospective study. Journal of medical Internet research. 2021 Apr 19;23(4):e24996. https://doi.org/10.2196/24996

Van Der Sijs H, Aarts J, Vulto A, Berg M. Overriding of drug safety alerts in computerized physician order entry. Journal of the American Medical Informatics Association. 2006 Mar 1;13(2):138-47. https://doi.org/10.1197/jamia.M1809

Herrin J, Abraham NS, Yao X, Noseworthy PA, Inselman J, Shah ND, Ngufor C. Comparative effectiveness of machine learning approaches for predicting gastrointestinal bleeds in patients receiving antithrombotic treatment. JAMA network open. 2021 May 3;4(5):e2110703-. doi:10.1001/jamanetworkopen.2021.10703

Alanazi SF. Comparative Evaluation of the Pharmacological Mechanisms, Clinical Indications, and Risk Management Strategies of Epidural Anesthesia in Surgical and Obstetric Interventions. Saudi Journal of Medicine and Public Health. 2024 Dec 25;1(1):47-57. https://doi.org/10.64483/jmph-36

Pontinha VM, Patterson JA, Dixon DL, Carroll NV, Mays DA, Farris KB, Holdford DA. Investigating the Time-Varying Nature of Medication Adherence Predictors: An Experimental Approach Using Andersen’s Behavioral Model of Health Services Use. Pharmacy. 2025 Apr 9;13(2):53. https://doi.org/10.3390/pharmacy13020053

Vervloet M, Linn AJ, van Weert JC, De Bakker DH, Bouvy ML, Van Dijk L. The effectiveness of interventions using electronic reminders to improve adherence to chronic medication: a systematic review of the literature. Journal of the American Medical Informatics Association. 2012 Sep 1;19(5):696-704. https://doi.org/10.1136/amiajnl-2011-000748

Hazazi YO. Strengthening Postpartum Depression Screening and Treatment within Primary Healthcare Centers in Riyadh 1st Cluster. Saudi Journal of Medicine and Public Health. 2025 Jul 26;2(2):105-13. https://doi.org/10.64483/jmph-56

Kelleher JD, Mac Namee B, D'arcy A. Fundamentals of machine learning for predictive data analytics: algorithms, worked examples, and case studies. MIT press; 2020 Oct 20.

Badakhshan P, Geyer-Klingeberg J, El-Halaby M, Lutzeyer T, Affonseca GV. Celonis Process Repository: A Bridge between Business Process Management and Process Mining. InBPM (PhD/Demos) 2020 Sep 13 (pp. 67-71).

Wang Y, Willis E, Yeruva V, Ho D, Lee Y. Using Natural Language Processing to Extract Intelligence for Public Health Crises. https://doi.org/10.21203/rs.3.rs-1934039/v1

fehaid hawas Alshammari Y. Interdisciplinary Approaches to Understanding and Managing Oral Microbiome Dysbiosis in Relation to Cardiovascular Disease Pathophysiology and Outcomes. Saudi Journal of Medicine and Public Health. 2024 Dec 25;1(1):27-36. https://doi.org/10.64483/jmph-17

Crown WH. Real-world evidence, causal inference, and machine learning. Value in Health. 2019 May 1;22(5):587-92. https://doi.org/10.1016/j.jval.2019.03.001

Garrison Jr LP, Jiao B, Dabbous O. Value-based pricing for patent-protected medicines over the product life cycle: pricing anomalies in the “age of cures” and their implications for dynamic efficiency. Value in Health. 2023 Mar 1;26(3):336-43. https://doi.org/10.1016/j.jval.2022.09.010

Claire R, Elvidge J, Hanif S, Goovaerts H, Rijnbeek PR, Jónsson P, Facey K, Dawoud D. Advancing the use of real world evidence in health technology assessment: insights from a multi-stakeholder workshop. Frontiers in pharmacology. 2024 Jan 12;14:1289365. https://doi.org/10.3389/fphar.2023.1289365

Beshbishy AM. Advancements in Vaccination Tracking and Delivery Systems through Health Informatics: A Review of Digital Innovations and COVID-19 Impact. Saudi Journal of Medicine and Public Health. 2024 Nov 28;1(S1):16-26. https://doi.org/10.64483/jmph-16

Neumann PJ, Cohen JT. Measuring the value of prescription drugs. New England Journal of Medicine. 2015 Dec 31;373(27):2595-7.

Pushpakom S, Iorio F, Eyers PA, Escott KJ, Hopper S, Wells A, Doig A, Guilliams T, Latimer J, McNamee C, Norris A. Drug repurposing: progress, challenges and recommendations. Nature reviews Drug discovery. 2019 Jan;18(1):41-58. doi:10.1038/nrd.2018.168

Ashburn TT, Thor KB. Drug repositioning: identifying and developing new uses for existing drugs. Nature reviews Drug discovery. 2004 Aug 1;3(8):673-83. https://doi.org/10.1038/nrd1468

Alsaigh MA, Almarhoon MA, Al Otaibi AA, ALSUMYL AM, Al Dossary SN, JAFARI AY, Al-Dosari NM, ALJAAFARI YA, HABKUR AQ, AlBishi HH. Interprofessional Collaboration for Improved Appointment Management: A Narrative Review of Integrating Secretarial and Nursing Roles. Saudi Journal of Medicine and Public Health. 2024 Dec 26;1(1):180-92. https://doi.org/10.64483/jmph-78

Ghassemi M, Oakden-Rayner L, Beam AL. The false hope of current approaches to explainable artificial intelligence in health care. The lancet digital health. 2021 Nov 1;3(11):e745-50. https://doi.org/10.1016/S2589-7500(21)00208-9

Price WN, Cohen IG. Privacy in the age of medical big data. Nature medicine. 2019 Jan;25(1):37-43. https://doi.org/10.1038/s41591-018-0272-7

Obermeyer Z, Powers B, Vogeli C, Mullainathan S. Dissecting racial bias in an algorithm used to manage the health of populations. Science. 2019 Oct 25;366(6464):447-53. https://doi.org/10.1126/science.aax2342

Rudin C. Stop explaining black box machine learning models for high stakes decisions and use interpretable models instead. Nature machine intelligence. 2019 May;1(5):206-15. https://doi.org/10.1038/s42256-019-0048-x

Steyerberg EW, Harrell Jr FE. Prediction models need appropriate internal, internal-external, and external validation. Journal of clinical epidemiology. 2015 Apr 18;69:245. https://doi.org/10.1016/j.jclinepi.2015.04.005

Food US. Drug Administration (FDA). Proposed Regulatory Framework for Modifications to Artificial Intelligence. Machine Learning (AI/ML)-Based Software as a Medical Device (SaMD)—Discussion Paper and Request for Feedback (US Food & Drug Administration (FDA), 2019). 2021.

Gerke S, Minssen T, Cohen G. Ethical and legal challenges of artificial intelligence-driven healthcare. InArtificial intelligence in healthcare 2020 Jan 1 (pp. 295-336). Academic Press. https://doi.org/10.1016/B978-0-12-818438-7.00012-5

Martini N, Sajtos L, Idio L, Kaur M, Sweeney N, Zhang C, Scahill S. The future of pharmacy work: how pharmacists are adapting to and preparing for technology infusion. Exploratory Research in Clinical and Social Pharmacy. 2024 Sep 1;15:100472. https://doi.org/10.1016/j.rcsop.2024.100472

Rieke N, Hancox J, Li W, Milletari F, Roth HR, Albarqouni S, Bakas S, Galtier MN, Landman BA, Maier-Hein K, Ourselin S. The future of digital health with federated learning. NPJ digital medicine. 2020 Sep 14;3(1):119. https://doi.org/10.1038/s41746-020-00323-1

Adadi A, Berrada M. Peeking inside the black-box: a survey on explainable artificial intelligence (XAI). IEEE access. 2018 Sep 16;6:52138-60. doi: 10.1109/ACCESS.2018.2870052

Agarwal U, Rishiwal V, Yadav M, Alshammari M, Yadav P, Singh O, Maurya V. Exploring blockchain and supply chain integration: State-of-the-art, security issues, and emerging directions. IEEE Access. 2024 Sep 30;12:143945-74. doi: 10.1109/ACCESS.2024.3471340

Relling MV, Evans WE. Pharmacogenomics in the clinic. Nature. 2015 Oct 15;526(7573):343-50. https://doi.org/10.1038/nature15817

Authors

Ahmed Ali Mussa Naji
Ahaji@moh.gov.sa (Primary Contact)
Rehab Moaied Abdo Bagal
Ali Hassan Ibrahim Khormi
Abdulrahman Yahya Ahmed Masrai
Asim Omar Mohammed Hakami
Ahmed Mohsen Mohammed Maswdi
Mohammed Saleh Mohammed Sayed
Ahmed Hussain Ahmed Zalah
Mohammed Mohsen Abdu Khormi
Talal Qasim Mosa Mashragi
Ibrahim Abu Bakr Hakami
Ahmad Nahari Mohammad Madkhali
Abdullah Mohsen Mohammed Maswdi
Ahmad Abdullah Ali Majrashi
Mazen Qassem Buhais Ozaybi
Radwan Yehya Salim Moudhah
Naji, A. A. M., Bagal, R. M. A., Khormi, A. H. I., Masrai, A. Y. A., Hakami, A. O. M., Maswdi, A. M. M., … Moudhah, R. Y. S. (2025). The Prescription for Value and Efficiency: A Systematic Review of Artificial Intelligence in Optimizing Pharmacy Business and Drug Prices. Saudi Journal of Medicine and Public Health, 2(2), 653–660. https://doi.org/10.64483/jmph-184

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